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Intelligent nanometer chiral selector material, as well as preparation and application thereof

A chiral selector and nanotechnology, applied in other chemical processes, alkali metal oxides/hydroxides, inorganic chemistry, etc., can solve problems such as difficult analysis and regeneration of chiral selectors, low efficiency, and high cost

Active Publication Date: 2018-07-20
SOUTHWEST UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The resolution methods for amino acid enantiomers in the prior art include chromatography, capillary electrophoresis, membrane separation, etc. These resolution methods usually have the disadvantages of complicated operation, high cost and low efficiency
[0004] Some existing technologies have further studied the feasibility of using certain magnetic nanomaterials as amino acid chiral resolution, such as the macrocyclic antibiotic body coplanin, bovine serum albumin or human serum albumin, etc. on silica-coated Fe 3 o 4 Nanoparticles are modified to prepare a series of magnetic nano-chiral selectors, but when these materials are used for the chiral resolution of amino acid enantiomers, there are usually complex operations, poor environmental friendliness, and it is difficult to quickly and easily resolve them after resolution. Realize the resolution of enantiomeric molecules and the regeneration of chiral selectors

Method used

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  • Intelligent nanometer chiral selector material, as well as preparation and application thereof
  • Intelligent nanometer chiral selector material, as well as preparation and application thereof
  • Intelligent nanometer chiral selector material, as well as preparation and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0066] The smart nanochiral selector material was prepared by the following process:

[0067] (1) Fe 3 o 4 Preparation of magnetic nanoparticles: 1.0gPSSMA, 1.08gFeCl3 6H 2 O. 3.0gNaAc was added to 40mL of ethylene glycol in turn, stirred vigorously for 30min, and transferred to a 100mL polytetrafluoroethylene-lined reactor after turning into a uniform brown-yellow solution, and reacted at 200°C for 10h. After the reaction, After the product was cooled to room temperature, it was subjected to magnetic separation, washed 4 to 5 times with deionized water, and dried under vacuum at room temperature overnight;

[0068] (2) Preparation of polydopamine-modified magnetic nanoparticles (Fe 3 o 4 @PDA): Weigh 100mg Fe 3 o 4 In a 150mL three-neck flask, add magnetic nanoparticles into 100mL Tris buffer solution, the buffer solution pH=8.5, obtained by dissolving 0.26g Tris in ethanol / water mixed solution (V / V=30 / 70), after ultrasonic dispersion for 30min Add 10 mL of DMF solutio...

Embodiment 2

[0102] The smart nanochiral selector material was prepared by the following process:

[0103] (1) Fe 3 o 4 Preparation of magnetic nanoparticles: 1.0gPSSMA, 1.08gFe 2 SO 4 , 3.0gNaAc were added to 40mL ethylene glycol in turn, stirred vigorously at a rate of 1000r / min for 30min, and transferred to a 100mL polytetrafluoroethylene-lined reactor after turning into a uniform brownish-yellow solution, and reacted at 198°C for 22h , after the reaction, the product was cooled to room temperature, subjected to magnetic separation, washed with deionized water for 4 to 5 times, and vacuum-dried overnight at room temperature;

[0104] (2) Preparation of polydopamine-modified magnetic nanoparticles (Fe 3 o 4 @PDA): Weigh 100mg Fe 3 o 4In a 150mL three-neck flask, add magnetic nanoparticles into 100mL Tris buffer solution, the buffer solution pH=8.5, obtained by dissolving 0.26g Tris in ethanol / water mixed solution (V / V=30 / 70), after ultrasonic dispersion for 30min Add 10 mL of DMF...

Embodiment 3

[0109] The smart nanochiral selector material was prepared by the following process:

[0110] (1) Fe 3 o 4 Preparation of magnetic nanoparticles: 1.0gPSSMA, 1.08gFe 2 SO 4 , 3.0gNaAc were added to 40mL of ethylene glycol in turn, stirred vigorously at a rate of 1200r / min for 30min, and transferred to a 100mL polytetrafluoroethylene-lined reactor after turning into a uniform brown-yellow solution, and reacted at 220°C for 6h , after the reaction, the product was cooled to room temperature, subjected to magnetic separation, washed with deionized water for 4 to 5 times, and vacuum-dried overnight at room temperature;

[0111] (2) Preparation of polydopamine-modified magnetic nanoparticles (Fe 3 o 4 @PDA): Weigh 100mg Fe 3 o 4 In a 150mL three-neck flask, add magnetic nanoparticles into 100mL Tris buffer solution, the buffer solution pH=8.8, obtained by dissolving 0.26g Tris in ethanol / water mixed solution (V / V=30 / 70), after ultrasonic dispersion for 30min Add 10 mL of DMF...

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Abstract

The invention discloses an intelligent nanometer chiral selector material, as well as preparation and application thereof. The preparation comprises the steps of firstly preparing Fe3O4 magnetic nanoparticles; then modifying the obtained Fe3O4 magnetic nanoparticles through polydopamine; and the like. The material provided by the invention has thermosensitivity, temperature-response chiral selectivity, and magnetic responsiveness, and is capable of quickly and simply decomposing an enantiomer molecule and regenerating the material after splitting an amino acid enantiomer.

Description

technical field [0001] The invention relates to the technical field of intelligent nano chiral materials. Background technique [0002] When more active ingredients or living substances are actually used, only a part with a specific chiral structure can be directly utilized by the human body. For example, amino acids, which are an important part of living organisms, actually have D configuration and L configuration. These two different configurations of amino acid enantiomers often have different effects. On the one hand, L-type amino acids are active on the human body, while D-type amino acids are not active, and may even have serious negative effects on the human body; on the other hand, D-type amino acids have other functions, such as participating in the regulation of hormone secretion, nerve Signal transmission, human aging and other physiological processes; in addition, the appearance or increase of D-amino acids in the human body also indicates the appearance of some...

Claims

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Application Information

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IPC IPC(8): C08G81/02B01J20/26B01J20/28
CPCB01J20/264B01J20/28009C08G81/02
Inventor 程昌敬宋晓东朱涵岩余海溶
Owner SOUTHWEST UNIVERSITY FOR NATIONALITIES
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