A kind of intelligent nano chiral selector material and its preparation and application

A chiral selector, nanotechnology, applied in other chemical processes, chemical instruments and methods, alkali metal compounds, etc., can solve the problems of difficult analysis and regeneration of chiral selectors, low efficiency and high cost

Active Publication Date: 2020-12-18
SOUTHWEST UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The resolution methods for amino acid enantiomers in the prior art include chromatography, capillary electrophoresis, membrane separation, etc. These resolution methods usually have the disadvantages of complicated operation, high cost and low efficiency
[0004] Some existing technologies have further studied the feasibility of using certain magnetic nanomaterials as amino acid chiral resolution, such as the macrocyclic antibiotic body coplanin, bovine serum albumin or human serum albumin, etc. on silica-coated Fe 3 o 4 Nanoparticles are modified to prepare a series of magnetic nano-chiral selectors, but when these materials are used for the chiral resolution of amino acid enantiomers, there are usually complex operations, poor environmental friendliness, and it is difficult to quickly and easily resolve them after resolution. Realize the resolution of enantiomeric molecules and the regeneration of chiral selectors

Method used

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  • A kind of intelligent nano chiral selector material and its preparation and application
  • A kind of intelligent nano chiral selector material and its preparation and application
  • A kind of intelligent nano chiral selector material and its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] The smart nanochiral selector material was prepared by the following process:

[0066] (1) Fe 3 o 4 Preparation of magnetic nanoparticles: 1.0gPSSMA, 1.08gFeCl3·6H 2 Add O and 3.0g NaAc to 40mL ethylene glycol in turn, stir vigorously for 30min, transfer to a 100mL polytetrafluoroethylene-lined reactor after turning into a uniform brown-yellow solution, and react at 200°C for 10h. , the product was cooled to room temperature, subjected to magnetic separation, washed with deionized water for 4 to 5 times, and vacuum-dried overnight at room temperature;

[0067] (2) Preparation of polydopamine-modified magnetic nanoparticles (Fe 3 o 4 @PDA): Weigh out 100mg Fe 3 o 4 In a 150mL three-neck flask, magnetic nanoparticles were added to 100mL Tris buffer solution, the buffer solution pH=8.5, obtained by dissolving 0.26g Tris in ethanol / water mixed solution (V / V=30 / 70), ultrasonically dispersed for 30 After 1 min, 10 mL of DMF solution in which 0.2 g of dopamine hydrochlo...

Embodiment 2

[0099] The smart nanochiral selector material was prepared by the following process:

[0100] (1) Fe 3 o 4 Preparation of magnetic nanoparticles: 1.0gPSSMA, 1.08gFe 2 SO 4, 3.0g NaAc were added to 40mL ethylene glycol in turn, stirred vigorously at a rate of 1000r / min for 30min, and transferred to a 100mL polytetrafluoroethylene-lined reactor after turning into a uniform brown-yellow solution, and reacted at 198°C for 22h After the reaction, the product was cooled to room temperature, subjected to magnetic separation, washed with deionized water for 4 to 5 times, and vacuum-dried overnight at room temperature;

[0101] (2) Preparation of polydopamine-modified magnetic nanoparticles (Fe 3 o 4 @PDA): Weigh out 100mg Fe 3 o 4 In a 150mL three-neck flask, magnetic nanoparticles were added to 100mL Tris buffer solution, the buffer solution pH=8.5, obtained by dissolving 0.26g Tris in ethanol / water mixed solution (V / V=30 / 70), ultrasonically dispersed for 30 After 1 min, 10 m...

Embodiment 3

[0106] The smart nanochiral selector material was prepared by the following process:

[0107] (1) Fe 3 o 4 Preparation of magnetic nanoparticles: 1.0gPSSMA, 1.08gFe 2 SO 4 , 3.0gNaAc were added to 40mL ethylene glycol in turn, stirred vigorously at a rate of 1200r / min for 30min, and after turning into a uniform brownish-yellow solution, transferred to a 100mL polytetrafluoroethylene-lined reactor and reacted at 220°C for 6h After the reaction, the product was cooled to room temperature, subjected to magnetic separation, washed with deionized water for 4 to 5 times, and vacuum-dried overnight at room temperature;

[0108] (2) Preparation of polydopamine-modified magnetic nanoparticles (Fe 3 o 4 @PDA): Weigh out 100mg Fe 3 o 4 In a 150mL three-necked flask, magnetic nanoparticles were added to 100mL Tris buffer solution, the buffer solution pH=8.8, obtained by dissolving 0.26g Tris in ethanol / water mixed solution (V / V=30 / 70), ultrasonically dispersed for 30 After 1 min, ...

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Abstract

The invention discloses an intelligent nanometer chiral selector material, as well as preparation and application thereof. The preparation comprises the steps of firstly preparing Fe3O4 magnetic nanoparticles; then modifying the obtained Fe3O4 magnetic nanoparticles through polydopamine; and the like. The material provided by the invention has thermosensitivity, temperature-response chiral selectivity, and magnetic responsiveness, and is capable of quickly and simply decomposing an enantiomer molecule and regenerating the material after splitting an amino acid enantiomer.

Description

technical field [0001] The invention relates to the technical field of intelligent nano chiral materials. Background technique [0002] When more active ingredients or living substances are actually used, only a part with a specific chiral structure can be directly utilized by the human body. For example, amino acids, which are important components of living organisms, actually exist D Configuration and L Configuration, these two different configurations of amino acid enantiomers often have different effects. on the one hand L Type amino acids are active to the human body, while D Type amino acids are not active, and may even have serious negative effects on the human body; on the other hand, D Type amino acids have other functions, such as participating in the regulation of hormone secretion, nerve signal transmission, and physiological processes such as human aging; in addition, D The appearance or increase of type amino acids in the human body also indicates the app...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G81/02B01J20/26B01J20/28
CPCB01J20/264B01J20/28009C08G81/02
Inventor 程昌敬宋晓东朱涵岩余海溶
Owner SOUTHWEST UNIVERSITY FOR NATIONALITIES
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