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Sulfur-containing Schiff base Zn-Na coordination polymer and preparation method and application thereof

A technology of coordination polymer and sulfur-containing Schiff base, which is applied in chemical instruments and methods, luminescent materials, antibacterial drugs, etc., can solve the problems of few research reports, etc. stable effect

Active Publication Date: 2018-07-20
HUNAN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Schiff base has antibacterial, bactericidal, antitumor, antiviral and other biological activities used in the medical field; in the field of catalysis, the zinc and nickel complexes of Schiff base have been used as catalysts; Schiff base can also be used as a good complex It can be used to identify and identify metal ions and quantitatively analyze the content of metal ions, which has attracted wide attention in the field of analysis. In simple Schiff base complexes, while there are few research reports on sulfur-containing heteronuclear complexes, the present invention reports the synthesis and application of a novel heteronuclear zinc-sodium complex

Method used

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  • Sulfur-containing Schiff base Zn-Na coordination polymer and preparation method and application thereof
  • Sulfur-containing Schiff base Zn-Na coordination polymer and preparation method and application thereof
  • Sulfur-containing Schiff base Zn-Na coordination polymer and preparation method and application thereof

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Effect test

Embodiment 1

[0041] Example 1 The synthesis of one-dimensional chain-like sulfur-containing Schiff base Zn-Na coordination polymers, the reaction steps are as follows:

[0042] Add 0.72mmol (162.19mg) o-vanillin thiosemicarbazone, 0.54mmol (about 118.54mg) zinc acetate, 0.8mmol (97.95mg) sodium perchlorate to 24mL N,N'-dimethylformamide , in a mixed solvent of acetonitrile and water (volume ratio 2:3:1), heated and refluxed in a water bath for 4 hours, adjusted the pH value to 6-8 with ammonia water, continued heating and stirring, controlled the temperature at 70°C, and reacted for 16 hours to obtain a colorless The solution was filtered, sealed, and naturally volatilized at room temperature. After three weeks, a light yellow crystal suitable for X-ray single crystal structure analysis was precipitated, with a yield of 52.36%. M.P.302~304℃; IR main absorption peaks are: 3245(w), 3434(m), 3275(m), 2912(w), 2805(w), 1580(vs), 1492(vs), 1439(vs ), 1296(s), 1232(s), 1140(m), 1113(m), 9676(m)...

Embodiment 2

[0044] Synthesis of One-dimensional Chain Sulfur-Containing Schiff Base Zn–Na Coordination Polymers

[0045] Add 0.64mmol (144.17mg) o-vanillin thiosemicarbazone, 0.56mmol (about 166.59mg) zinc nitrate hexahydrate, 0.54mmol (76.71mg) sodium sulfate to 30mL N,N'-dimethylacetamide , in a mixed solvent of acetonitrile and tetrahydrofuran (volume ratio 1:3:2), heat and reflux in a water bath for 3-5 hours, use ethylenediamine to adjust the pH value to 6-8, continue heating and stirring, control the temperature at 80°C, and react for 15-5 hours. After 18 hours, a light yellow solution was obtained, which was filtered, sealed, and evaporated naturally at room temperature. After three weeks, a light yellow crystal suitable for X-ray single crystal structure analysis was precipitated, with a yield of 53.62%.

Embodiment 3

[0047] Synthesis of One-dimensional Chain Sulfur-Containing Schiff Base Zn–Na Coordination Polymers

[0048] Add 0.48mmol (108.13mg) o-vanillin thiosemicarbazone, 0.48mmol (about 137.35mg) zinc sulfate heptahydrate, 0.48mmol (65.32mg) sodium acetate to 25mL N,N'-dimethylacetamide , in a mixed solvent of tetrahydrofuran and ethanol (volume ratio 5:10:8), heat and reflux in a water bath for 3 to 5 hours, adjust the pH value to 6 to 8 with triethylamine, continue heating and stirring, and control the temperature at 70 to 80°C. After ~20 hours, a light yellow solution was obtained, which was filtered, sealed, and naturally volatilized at room temperature. After three weeks, a light yellow crystal suitable for X-ray single crystal structure analysis was precipitated, with a yield of 54.21%.

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Abstract

The invention relates to synthesis and application of a sulfur-containing Schiff base Zn-Na coordination polymer. The sulfur Schiff base coordination polymer is prepared from O-vanillin-thiosemicarbazone, zinc salt and sodium salt as raw materials with a solvent method by adopting alkali to adjust pH, and crystals are obtained by self-volatilization crystallization. The complex has one-dimensionalchain-like structure, is easy to synthesize, convenient to purify, higher in yield and good in stability in air. Compared with the sulfur-containing Schiff base ligand, the complex has the advantagesthat the antibacterial property is significantly improved, and metal ions play a regulating role in antibacterial activity.

Description

technical field [0001] The invention relates to a sulfur-containing Schiff base coordination polymer, in particular to a one-dimensional chain Zn-Na heteronuclear sulfur-containing Schiff base coordination polymer and a preparation method thereof, and a one-dimensional chain Zn-Na heteronuclear The sulfur-containing Schiff base coordination polymer is used as an antibacterial compound in the preparation of antibacterial drug agents, and belongs to the field of synthesis of new biological medicines. Background technique [0002] Schiff base mainly refers to the imine or methylimine characteristic group compound containing carbon-nitrogen double bond, due to its unique optical, electrical, magnetic and other physical material properties, good coordination chemical properties and unique antibacterial, anticancer , Weeding and other physiological activities have aroused extensive theoretical and applied research. Schiff bases and their metal complexes have important application...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00C09K11/06A61P31/04
CPCC08G83/008C09K11/06C09K2211/181C09K2211/188
Inventor 李昶红李薇李安伍
Owner HUNAN INST OF TECH
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