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Application of sulfoxide compound in treatment of inflammatory bowel diseases

A technology of inflammatory bowel disease and sulfone compounds, applied in the field of pharmacy, can solve the problems of large side effects, high incidence, and inability to use for a long time

Active Publication Date: 2018-08-03
TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the side effects are relatively large and the incidence rate is relatively high, so it cannot be used for a long time
Among biological agents, TNF-t and a monoclonal antibodies are new drugs used in the treatment of IBD in recent years. They have shown good effects in controlling disease symptoms and promoting mucosal healing. At present, infliximab is mainly used (infliximab, IFX) and adalimumab (adalimumab), but only for maintenance therapy

Method used

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  • Application of sulfoxide compound in treatment of inflammatory bowel diseases
  • Application of sulfoxide compound in treatment of inflammatory bowel diseases
  • Application of sulfoxide compound in treatment of inflammatory bowel diseases

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Embodiment Construction

[0025] In order to better illustrate the present invention, specific embodiments of the present invention will be described in detail below.

[0026] The present invention provides an application of a sulfoxide compound in the treatment of inflammatory bowel disease, wherein the sulfoxide compound has the following general formula (I) structure:

[0027]

[0028] In the following examples, three inflammatory bowel disease models of ulcerative colitis in the acute phase, ulcerative colitis in the chronic phase and Crohn's disease were used to evaluate the efficacy of JY4, but the present invention is not limited in any way.

[0029] (1) Study on the therapeutic effect of JY4 on mice in the acute phase of ulcerative colitis

[0030] 1.1 Experimental method

[0031] The animal strain used in this experiment is BALB / c mouse (albino laboratory mouse), female, 18-22 g, SPF (Specific Pathogen Free) level, and a total of 48 test drugs: compound JY4. Positive control drug: sulfasa...

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Abstract

The invention provides an application of a sulfoxide compound in the treatment of inflammatory bowel diseases. The sulfoxide compound has a structure represented by general formula (I) shown in the description. The sulfoxide compound has treatment effects on acute ulcerative colitis mice, chronic ulcerative colitis mice and Crohn's disease mice, and can be applied to drugs for treating or preventing the inflammatory bowel diseases.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to the application of a sulfoxide compound in the treatment of inflammatory bowel disease. Background technique [0002] Inflammatory bowel disease (IBD) is a chronic non-specific intestinal inflammatory disease with recurrent course. Clinically, it mainly manifests as abdominal pain, diarrhea, mucus, pus and blood in the stool, and tenesmus. The pathological feature is colonic mucosa Chronic inflammation, intestinal mucosal ulceration or transmural granuloma formation. Epidemiological studies have found that the incidence of IBD in North America and Northern Europe is relatively high, but in recent years the incidence in the Asia-Pacific region has gradually increased, and China has become one of the countries with a higher incidence in Asia. IBD tends to occur in young adults, with an average age of onset of 39 years, and is more common in men, accounting for 59%. Inflammatory b...

Claims

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Application Information

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IPC IPC(8): A61K31/27A61P1/04A61P1/00
CPCA61K31/27A61P1/00A61P1/04
Inventor 饶子和杨诚孙涛白翠改赵秀娟孙桐艳李慧影刘艳荣路俊李晓慧陈璐
Owner TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE
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