Nutritional compositions and infant formulas to promote myelination in the brain

A nutritional composition and composition technology, applied in the direction of medical preparations containing active ingredients, drug combinations, food ingredients, etc., can solve the problem of not providing myelin formation track

Pending Publication Date: 2018-08-03
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, studies have shown that standard infant formula often does not provide this optimal myelination trajectory

Method used

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  • Nutritional compositions and infant formulas to promote myelination in the brain
  • Nutritional compositions and infant formulas to promote myelination in the brain
  • Nutritional compositions and infant formulas to promote myelination in the brain

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Experimental program
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specific Embodiment approach

[0199] For the sake of clarity, all embodiments and aspects reported below shall apply mutatis mutandis to the different embodiments and aspects described for the invention.

[0200] All indicated amounts for nutritional substances are expressed per dry weight of the nutritional composition, unless otherwise indicated.

[0201] Where the nutrient may be included in the composition in different forms (either by itself or in the form of a salt, complex or more complex structure comprising the nutrient), the amounts reported below shall be intended to refer to the nutrient itself. quantity.

[0202] The nutritional composition according to the invention comprises phospholipids, their metabolic precursors and / or their metabolites.

[0203] It may be particularly advantageous if the composition according to the invention also comprises one or more of the following ingredients: vitamins and / or minerals and / or fatty acid derivatives and / or choline.

[0204] Phospholipids, their met...

Embodiment 1

[0454] Identification of nutritional drivers by cross-sectional analysis

[0455] From the above cohort, children up to 5 years of age who were fed different infant formulas during infancy were included in a large correlation analysis to examine the relationship between the nutritional composition of the formula and brain myelination. The nutritional composition of the 5 most commonly used formulas in this group was analyzed. Construct a single general linear model (GLM) that simulates all quantified nutrients, sphingomyelin and child age. Voxel-wise correlations were calculated, with significance defined as p<0.05, corrected for type I errors using a cluster-based correction method.

[0456] In the initial analysis, the inclusion of all nutrients resulted in an underpowered model. To reduce the number of variables in the model, we tested for correlations among variables. Using a conservative threshold of 0.9, we excluded variables (nutrient components) that were highly c...

Embodiment 2

[0460] Myelination trajectories according to longitudinal studies

[0461] Based on the available data, a longitudinal trajectory analysis was performed for two formulas containing different amounts of the identified nutritional driver, sphingomyelin (the composition of these formulas is reported in Table 2 below):

[0462] Table 2 :

[0463]

[0464] result in figure 1 reported in.

[0465] The graph shows that the higher the sphingomyelin content of the formula, the closer the myelination trajectory of infants fed that formula resembled that provided by human breastfeeding alone.

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Abstract

The invention relates to a nutritional composition for infants and young children, such as an infant formula or follow-on formula or growing up milk, preferably an infant formula, and comprising a phospholipid, a metabolic precursor and / or a metabolite thereof. The phospholipid promotes and / or supports an optimal myelination trajectory in the brain, such trajectory being close to that observed ininfants fed exclusively with human breast milk (HBM). The infants or young children can be between 0 and 60 months, preferably between 0 and 12 months of age.

Description

technical field [0001] The present invention relates to nutritional compositions for infants and young children and their associated health benefits. In particular, it relates to nutritional compositions comprising phospholipids, their metabolic precursors and / or their metabolites for promoting or supporting an optimal myelination trajectory in the brain, which is close to that seen during the first few hours of life. trajectories observed in infants fed exclusively with human breast milk (HBM). Background technique [0002] Whenever a mother is unable to breastfeed her infant, infant formula can provide a suitable alternative to natural feeding with human breast milk. Nutritional compositions for infants and young children are usually sold as powders for reconstitution with water or in some cases as ready-to-drink or concentrated liquid compositions. These compositions are intended to cover most or all of the nutritional needs of an infant or young child. [0003] Howeve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/12A23L33/105A23L33/15A23L33/16A61P25/00A23L33/00A61K45/00
CPCA61K31/14A61K31/202A61K31/519A61K31/688A61K33/26A23V2002/00A23L33/40A23L33/105A23L33/15A23L33/16A61K45/00A23L33/12A61P25/28A23V2200/322A23V2250/1592A23V2250/186A23V2250/1868A23V2250/7056A61K2300/00A23V2250/1846A23V2250/185
Inventor N·施耐德S·迪奥尼T·巴尔特福伊
Owner SOC DES PROD NESTLE SA
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