Preparation method of ganoderma lucidum polysaccharide with high antineoplastic activity and equipment thereof

A technology of anti-tumor activity and Ganoderma lucidum polysaccharides, which is applied in the direction of anti-tumor drugs, organic active ingredients, medical preparations containing active ingredients, etc., can solve the problems of low purity and activity of extracted polysaccharides, and avoid polysaccharides from being oxidized and production costs Low, high antitumor activity

Active Publication Date: 2018-08-14
福建仙芝楼生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] Aiming at the problems of low purity and low activity of polysaccharides extracted by the above-mentioned technology and process, the present invention innovates the extraction technology of Ganoderma luci...

Method used

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  • Preparation method of ganoderma lucidum polysaccharide with high antineoplastic activity and equipment thereof
  • Preparation method of ganoderma lucidum polysaccharide with high antineoplastic activity and equipment thereof
  • Preparation method of ganoderma lucidum polysaccharide with high antineoplastic activity and equipment thereof

Examples

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Effect test

Embodiment 1

[0028] Example 1: A preparation method of Ganoderma lucidum polysaccharide with high anti-tumor activity. The original medicinal material of Ganoderma lucidum is crushed into 1kg of Ganoderma lucidum granules of 10-30 meshes, and put into supercritical CO 2 In the extraction tank of the extraction device, seal it and feed it with supercritical carbon dioxide. Under the conditions of pressure 650bar and temperature 60°C, conduct static extraction for 30 minutes, then open the high-pressure pump and valve for dynamic extraction, adjust the pressure of the separation tank to 80bar, and the temperature to 30°C , to control CO 2 The flow rate is 10kg / h. After 3.0h of circulation extraction, the mixture of fat-soluble and partly low-polar components such as oil, triterpenes and pigments is collected from the separation tank. Stop the extraction, open the exhaust valve to quickly relieve the pressure, CO 2 After the extraction is finished, add 4kg of clean water to the extraction ta...

Embodiment 2

[0029] Example 2: A technology and preparation method of Ganoderma lucidum polysaccharide with high anti-tumor activity, the original medicinal material of Ganoderma lucidum is crushed into 1kg of Ganoderma lucidum granules of 10-30 meshes, and put into supercritical CO 2 In the extraction tank of the extraction device, seal it and feed it with supercritical carbon dioxide. Under the conditions of pressure 850bar and temperature 50°C, conduct static extraction for 30 minutes, then open the high-pressure pump and valve for dynamic extraction, and adjust the pressure of the separation tank to 100bar and temperature 50°C. , to control CO 2 The flow rate is 12kg / h, and after 4.0h of such circular extraction, the mixture of fat-soluble and partially low-polar components such as oil, triterpenes and pigments is collected from the separation tank. Stop the extraction, open the exhaust valve to quickly relieve the pressure, CO 2 After the extraction is finished, add 5kg of clean wate...

Embodiment 3

[0030] Example 3: A technology and preparation method of Ganoderma lucidum polysaccharide with high anti-tumor activity. The raw medicinal material of Ganoderma lucidum is crushed into 1 kg of Ganoderma lucidum particles of about 10-30 meshes, and put into supercritical CO 2 In the extraction tank of the extraction device, seal it and feed it with supercritical carbon dioxide. Under the conditions of pressure 1050bar and temperature 40°C, conduct static extraction for 30 minutes, then open the high-pressure pump and valve for dynamic extraction, and adjust the pressure of the separation tank to 120bar and temperature 40°C. , to control CO 2 The flow rate is 14kg / h, and after 2.0h of such circular extraction, the mixture of fat-soluble and partly low-polar components such as oil, triterpenes and pigments is collected from the separation tank. stop extraction, CO 2 After the extraction is finished, add 6kg of clean water to the extraction tank, heat it up to 70-80°C, and pass i...

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Abstract

The invention discloses a preparation method of ganoderma lucidum polysaccharide with high antineoplastic activity. The preparation method is characterized by comprising the manufacturing steps: 1) smashing a ganoderma lucidum raw medicinal material into 10 to 30-mesh ganoderma lucidum particles; 2) putting the smashed ganoderma lucidum particles into an extraction tank of a high-pressure supercritical extraction device, sealing, turning on a high-pressure pump to inflate CO2, pressurizing to 600 to 2000bar, controlling a temperature as 40 to 60 DEG C, performing static extraction for 30 to 60min, turning on a fine adjustment valve, performing dynamic extraction and performing circular extraction for 2 to 4h under the conditions that separation tank pressure is 80 to 120bar, a temperatureis 30 to 50 DEG C, and a CO2 flow is controlled as 10 to 16kg/h; 3) water extraction: after CO2 extraction, adding water into the extraction tank, heating to 70 to 80 DEG C, inflating CO2, pressurizing to 80 to 100bar, performing pressure maintaining extraction for 1.5 to 3h and performing vacuum concentration and freeze drying to obtain light brown ganoderma lucidum polysaccharide. The extractionseparation method disclosed by the invention has the advantages of simpleness and suitability for industrial production; the prepared ganoderma lucidum polysaccharide extract has strong antineoplastic activity.

Description

technical field [0001] The invention relates to a preparation method of Ganoderma lucidum polysaccharide with high anti-tumor activity, which belongs to the field of deep processing of edible and medicinal fungi, especially high-pressure supercritical CO 2 A method for increasing the antitumor activity of Ganoderma lucidum polysaccharides by extracting and removing impurities. Background technique [0002] Ganoderma lucidum, also known as auspicious grass and fairy grass, is flat in nature and sweet in taste. It is a precious traditional Chinese medicine in my country. Traditional Chinese medicine has long been regarded as a precious Chinese herbal medicine for nourishing and strengthening the body, strengthening the body and strengthening the body. The components of Ganoderma lucidum are very rich, including more than a dozen kinds of polysaccharides, triterpenes and sterols, nucleosides, proteins, and trace elements. Among them, polysaccharides of Ganoderma lucidum have an...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/715A61P35/00
CPCA61P35/00A61K31/715C08B37/0003Y02P20/54
Inventor 李晔华正根姚渭溪王金亮朱丽萍吴长辉
Owner 福建仙芝楼生物科技有限公司
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