Synchronous High Resolution Multi-Wavelength Coherent Anti-Stokes Raman Scattering Source

Abstract

The invention relates to a synchronous high-resolution multi-wavelength coherent anti-Stokes Raman scattering light source. The light source disclosed in the invention is an optical parameter oscillator; in the optical parameter oscillator, pump light and coherent anti-Stokes light are subjected to intra-cavity frequency doubling through a dual-wavelength frequency doubling module, and then through a filtering output module and two long-wave output modules, two high-frequency component laser and the residual two low-frequency component laser after intra-cavity frequency doubling are output separately to be applied to CARS imaging. Two groups of synchronous laser in four beams in total can be output synchronously; through the intra-cavity dual-wavelength frequency doubling module, the spectral width of the light source is compressed, and the resolution of the CARS light source is improved; through a feedback time-delay system, a CARS scanning range is expanded, parameter conversion efficiency is improved, and synchronous high-resolution multi-wavelength laser output is realized; and the light source can synchronously obtain sample information of absorption peaks of high wave numberand low wave number from a biological sample, so that the detection capability of a CARS technology on vibration conversion energy levels of the biological sample in different wave numbers can be expanded.

Description

technical field [0001] The invention relates to a laser Raman scattering spectrum detection technology, in particular to a synchronous high-resolution multi-wavelength coherent anti-Stokes Raman scattering light source. Background technique [0002] The advancement of microscopic imaging technology has greatly promoted the development of modern biomedicine, and the research of modern biomedicine has made people's requirements for microscopic imaging technology higher and higher. Optical imaging technology has the characteristics of non-contact measurement, non-destructive testing, high sensitivity and good resolution. Among them, the fluorescent labeling method has the advantages of high acquisition sensitivity and a wide variety of labeled items, but the fluorescent labeling method will interfere with the normal metabolism of biological tissues, and sometimes the fluorescent agent may even kill biologically active cells. Coherent anti-Stokes Raman scattering (CARS) uses th...

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Problems solved by technology

Among the above three schemes, the narrowing of the pump light requires special customized devices, the multi-stage spatial filtering loses the possibility of all-fiber integration, and the special photonic crystal fiber with multiple zero-dispersion wavelengths is heavily dependent on the material manufacturing process. In the stage of laboratory verification, mass production is not yet possible. The conversion efficiency of external frequency doubling and filtering is low, and the energy utilization rate is limited.

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