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A kind of erythromycin ethylsuccinate dry suspension and preparation method thereof

A technology of erythromycin ethylsuccinate and dry suspension, which is applied in the direction of pharmaceutical formulations, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., and can solve the problem of poor redispersibility and erythromycin ethylsuccinate To solve the problems of poor flocculation effect of plain dry suspension, to achieve the effect of improving clinical curative effect, rapid absorption in gastrointestinal tract, and improving compliance

Active Publication Date: 2020-12-29
山西皇城相府药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention well solves the problems of poor flocculation effect and poor redispersibility of the erythromycin ethylsuccinate dry suspension in the prior art; meanwhile, the mouthfeel and color of the preparation are improved to improve patient compliance

Method used

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  • A kind of erythromycin ethylsuccinate dry suspension and preparation method thereof
  • A kind of erythromycin ethylsuccinate dry suspension and preparation method thereof
  • A kind of erythromycin ethylsuccinate dry suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 A kind of ethylsuccinate erythromycin dry suspension

[0039] The raw material composition is shown in Table 1, wherein 1 part by weight = 1 g.

[0040] The erythromycin ethylsuccinate dry suspension is prepared by the following method:

[0041] 1. Prepare each component according to the weight ratio, and pulverize;

[0042] II. get the stevioside of 1 / 3 described weight portion, tartrazine, sodium lauryl sulfate and ethylsuccinate erythromycin of 1 / 2 described weight portion, the sucrose powder of 2 / 3 described weight portion, press Mix in equal increments, and granulate with 20% ethanol aqueous solution (24ml) with a volume of 0.048 times the weight percentage of the total mass of the mixed dry material to obtain loose granules that are agglomerated by hand, loose by hand, and have rough edges. and powder, part A, 515g in total;

[0043] III. get stevioside, tartrazine, sodium lauryl sulfate, erythromycin ethylsuccinate and sucrose powder of remaining we...

Embodiment 2

[0047] Example 2 A kind of ethylsuccinate erythromycin dry suspension

[0048] The raw material composition is shown in Table 1, wherein 1 part by weight = 1 g.

[0049] By the same method and steps as in Example 1, 940 bags of erythromycin ethylsuccinate dry suspension (0.1 g / bag in terms of erythromycin ethylsuccinate) were prepared.

[0050] The erythromycin ethylsuccinate dry suspension prepared in this example is light yellow granules and a small amount of powder. After adding an appropriate amount of water and shaking the container slightly, it becomes a uniform suspension with good taste, fragrance and moderate sweetness.

Embodiment 3

[0051] Example 3 A kind of ethylsuccinate erythromycin dry suspension

[0052] The raw material composition is shown in Table 1, wherein 1 part by weight = 1 g.

[0053] By the same method and steps as in Example 1, 1045 bags of erythromycin ethylsuccinate dry suspension (0.1 g / bag in terms of erythromycin ethylsuccinate) were prepared.

[0054] The erythromycin ethylsuccinate dry suspension prepared in this example is light yellow granules and a small amount of powder. After adding an appropriate amount of water and shaking the container slightly, it becomes a uniform suspension with good taste, fragrance and moderate sweetness.

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Abstract

The invention provides erythromycin ethylsuccinate dry suspension and a preparation method thereof. The erythromycin ethylsuccinate dry suspension is prepared from the raw materials of 120 to 130 weight parts of erythromycin ethylsuccinate, 630 to 670 weight parts of saccharose powder, 10 to 20 weight parts of sodium alginate, 1 to 3 weight parts of steviosin, 5 to 15 weight parts of hydroxy propyl cellulose, 1 to 3 weight parts of lauryl sodium sulfate, 0.4 to 0.8 weight part of lemon yellow and 5 to 15 weight parts of sodium carboxymethyl starch. The sedimentation volume ratio F of the erythromycin ethylsuccinate dry suspension disclosed by the invention is very close to 1, a flocculation degree beta of the erythromycin ethylsuccinate dry suspension is about 6.0, and redispersibility ofthe erythromycin ethylsuccinate dry suspension is larger than or equal to 95%; thus, the suspension can be evenly dispersed in water, the problem that erythromycin ethylsuccinate dry suspension in theprior art can form much small micelle after water is added into the erythromycin ethylsuccinate dry suspension according to an instruction book is solved, clinical use experience is improved, and patient compliance is improved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a dry suspension of erythromycin ethylsuccinate and a preparation method thereof. Background technique [0002] Suspension refers to the inhomogeneous liquid preparation formed by dispersing insoluble solid drugs in a liquid medium with particles larger than colloidal particles, and is suitable for insoluble drugs whose required dose cannot be completely dissolved in a given volume of solvent, or Medicines that taste bad and are hard to swallow. Suspension is a thermodynamically unstable system, which requires that the chemical properties of the drug itself should be stable, the sedimentation speed should be slow, there should be no agglomeration after sedimentation, and it should be dispersed quickly and evenly after shaking. In the suspension, the drug is dispersed in the state of fine particles, the dispersion degree is large, the gastrointestinal tract ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K47/38A61K47/36A61K47/26A61K31/7048A61P31/04
CPCA61K9/1623A61K9/1652A61K31/7048A61P31/04
Inventor 马路军刘志红
Owner 山西皇城相府药业股份有限公司
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