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Graphene oxide/lidocaine sponge dressing and preparation method thereof

A technology of lidocaine and lidocaine, which is applied in the field of graphene oxide/lidocaine sponge dressing and its preparation, can solve the problems of hindering the epithelialization of tissue cells, easy penetration of pathogens, and foreign body reactions, etc., and achieve raw material selection And the effect of scientific and reasonable proportioning, great pain relief and simple production process

Active Publication Date: 2019-11-22
万绵水
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In view of the above situation, gauze is traditionally used as a medical dressing. Gauze has the advantages of protecting the wound surface, wide sources, simple production, and low price; but the disadvantages are also prominent: it cannot keep the wound moist, hinders the epithelialization of tissue cells, and delays wound healing; The fibers are easy to fall off, causing foreign body reactions and affecting healing; the wound granulation tissue is easy to grow into the mesh of the dressing, and it is easy to cause pain when changing the dressing; the hemostatic effect is not good, and the pathogens are easy to penetrate; the new tissue is easy to be damaged when changing the dressing; changing the dressing heavy workload

Method used

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  • Graphene oxide/lidocaine sponge dressing and preparation method thereof

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preparation example Construction

[0025] In addition, for the sponge dressing of the present invention, the applicant specifically provides a preparation method, such as figure 1 shown, including the following steps:

[0026] S101: Add polyvinyl alcohol to 5-10 times the amount of deionized water, gradually stir and heat up to 90° C. to completely dissolve, and then cool to room temperature to obtain an aqueous solution of polyvinyl alcohol.

[0027] S102: Add the graphene oxide / lidocaine clathrate into the polyvinyl alcohol aqueous solution, and stir evenly to obtain a graphene oxide / lidocaine polyvinyl alcohol blend.

[0028] S103: Add a foaming agent to the graphene oxide / lidocaine polyvinyl alcohol blend, and stir well and evenly.

[0029] S104: Add a catalyst to the solution obtained in S103, and stir at 25-30° C. for 3-5 minutes.

[0030] S105: Add a crosslinking agent to the product obtained in S104 and continue to react for 20-25 minutes, bake the reaction product at 50-70° C., and then press-wash un...

Embodiment 1

[0036]This embodiment provides a preparation method of graphene oxide, comprising the following steps: prepare graphite into graphene oxide, put 3g of graphite powder in a 500mL single-necked flask, then add 300mL of sulfuric acid and phosphoric acid mixed acid, slowly add permanganate Potassium, seal with a parafilm at 50°C, stir for 15 hours, cool to room temperature, use a 400mL ice-water bath, and add hydrogen peroxide with a mass percentage concentration of 30% under the condition of an ice-water bath, and add it slowly until the solution turns bright yellow , low-speed centrifugation; move the centrifuged product to a beaker, add hydrochloric acid to wash twice, add ethanol to wash twice, and wash twice with deionized water until the pH value of the supernatant reaches neutrality, then freeze-dry the product That is graphene oxide.

Embodiment 2

[0038] Based on the graphene oxide prepared in Example 1, this embodiment provides a method for preparing a graphene oxide / lidocaine clathrate, comprising the following steps:

[0039] 50 mg of graphene oxide was added to 25 mL of deionized water and ultrasonically treated for 30 min, and the graphene oxide solution was transferred to a 100 mL round bottom flask to obtain a graphene oxide dispersion. Weigh 200mg of lidocaine hydrochloride, dissolve it in 3mL of absolute ethanol, then add 7mL of graphene oxide dispersion, ultrasonicate for 30min, and the ultrasonic power is 400W, the frequency is 40kHz; then stir overnight, adjust the pH value to below 6, obtained Graphene oxide / lidocaine clathrate with a concentration of 20mg / mL; then place it in a refrigerator at 4°C for later use.

[0040] The graphene oxide / lidocaine clathrate prepared in Example 2 is used in the preparation process of sponge dressing, specifically including the following examples:

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Abstract

The invention discloses a graphene oxide / lidocaine sponge dressing and a preparation method thereof. The sponge dressing is prepared from the following raw material components: 20 to 500g of polyvinylalcohol, 1 to 20mL of graphene oxide / lidocaine inclusion complex, 0.01 to 15g of foaming agent, 10 to 400mL of catalyst and 10 to 400mL of cross-linking agent, wherein the concentration of the graphene oxide / lidocaine inclusion complex is 5 to 20mg / mL. Compared with the prior art, the medical sponge dressing integrates the excellent performance of graphene oxide, lidocaine, polyvinyl alcohol andthe like, has the advantages of rapid liquid absorbing, large liquid absorbing amount, large moisture-locking amount, antibacterial activity, analgesis, flexibility, high elasticity and the like, andcan be used for quickly treating wounded skin of a patient and reducing the huge pain caused by the wound surface. In addition, the medical sponge dressing provided by the invention is simple in production process, low in cost, easy to realize industrial production, and has wide application value.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a graphene oxide / lidocaine sponge dressing and a preparation method thereof. Background technique [0002] In recent years, with the rapid development of the transportation industry, petrochemical industry, construction industry, etc., the incidence, disability rate and death rate of burns in work and daily life are all increasing year by year. According to statistics, in my country's annual death toll due to accidental injuries, burns rank second, second only to traffic accident injuries. Among them, the annual incidence of burns in my country is about 2%, and about 5% of burn patients need hospitalization, and about 10% of hospitalized burn patients suffer from disabilities in varying degrees, which is a heavy burden on patients themselves, their families and society. It is a major issue related to family happiness and social stability. Therefore, when the skin is...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/20A61L15/18A61L15/24A61L15/42A61L15/44A61L15/46
CPCA61L15/18A61L15/20A61L15/24A61L15/42A61L15/425A61L15/44A61L15/46A61L2300/402A61L2300/404A61L2300/602A61L2400/12C08L29/04
Inventor 万绵水
Owner 万绵水
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