Diagnostics and pharmaceuticals containing adamts13 as a main ingredient

A chemotherapy and kit technology, applied in the field of medical drugs, can solve the problems of ineffective plasma exchange and reduce the recurrence rate
CN108463729BActive Publication Date: 2021-03-19KYOTO UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
KYOTO UNIV
Publication Date
2021-03-19

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Abstract

The invention provides a new application of ADAMTS13 in the medical field. The application of ADAMTS13 as a biomarker for monitoring the onset of liver dysfunction, hepatic ischemia / reperfusion disorder, or liver function after liver transplantation; the detection method of liver dysfunction and the detection method of liver ischemia / reperfusion disorder , or a method for examining liver function after liver transplantation, said method comprising measuring or monitoring ADAMTS13 activity in a sample obtained from a mammal; selected from liver dysfunction, liver ischemia / reperfusion disorder and liver function after liver transplantation A therapeutic agent for a disordered disease comprising ADAMTS13 or a modified form of ADAMTS13.
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Description

technical field

[0001] The present invention relates to proteins in the field of medical drugs. Specifically, a full-length or partial fragment of a specific cleavage enzyme (hereinafter referred to as "ADAMTS13") related to von Willebrand Factor (von Willebrand Factor: hereinafter sometimes referred to as "vWF") involved in blood coagulation is clinically new uses of the field. Specifically, the present invention relates to the novel use of the full-length or partial fragments of ADAMTS13 in the fields of liver dysfunction, liver ischemia / reperfusion disorder and liver transplantation. Background technique

[0002] The liver is an important organ responsible for metabolism, detoxification (detoxification of alcohol or harmful substances), and biological defense (immunity). Acute hepatitis mainly refers to a disease showing acute liver dysfunction caused by hepatitis virus infection, and its symptoms include jaundice, loss of appetite, vomiting, general fatigue, and fever....

Claims

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