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Optical detection of a substance in fluid

A technology of optical detection and optical detector, which is applied in the field of optical detection of substances in fluids, can solve problems such as detection, fluorescence or luminescence response difficulties, and achieve the effects of cost reduction, cost reduction, design and function simplification

Active Publication Date: 2018-08-31
МИНИКЭАР Б.В.
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Fluorescent or luminescent responses are difficult to detect in opaque samples due to absorption and scattering of the emitted wavelength in the sample

Method used

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  • Optical detection of a substance in fluid
  • Optical detection of a substance in fluid
  • Optical detection of a substance in fluid

Examples

Experimental program
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Embodiment Construction

[0067] figure 1 A schematic diagram of a TIR system 1 comprising a reading system 100 and a platform 300 is shown. Platform 300 is embedded with particles 400 and has sensor surface 350 extending between transparent window 340 and fluid container 330 . The platform 300 and the reading system 100 are arranged to operate in close proximity to each other such that the reading system 100 can transmit light (and / or other electromagnetic waves) to and receive light (and / or other electromagnetic waves) from the sensor surface 350 of the platform 300. other electromagnetic waves).

[0068] In particular, the reading system 100 includes:

[0069] a light emitter 101, such as at least one light emitting diode (LED) or laser, to emit a light beam or wave 10 onto the platform 300;

[0070] Arrangement for receiving sensor platform 300 (in figure 1 Not referenced in), so that the sensor surface 350 can receive the light emitted from the light emitter 101;

[0071] A light detector 102...

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PUM

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Abstract

The invention relates to a system (1) for optically detecting at least one substance in a fluid (200). The system (1) comprises particles (400, 410) arranged to be dispersed in the fluid (200), each one comprising a magnetic bead (400) and an agent (410). The agent (410) is reactive with said substance such that it gives a specific optical response upon a determined optical excitation or a chemical reaction. The system (1) further comprises a chamber (330) to contain said fluid (200) and particles (400, 410). The chamber (330) is closed at one side by a window (310) optically transparent to the wavelengths of said optical response and said optical excitation. The system (1) further comprises an optical detector (100) adapted to detect at least a portion of said optical response. The system(1) further comprises magnetic sources (103) arranged to magnetically move the particles (400, 410) onto or close to the window (310). The optical detector (100) is positioned to receive at least a portion of the optical response from the at least one agent (410) located onto or close to the window (310). The invention relates further to a disposable and a method.

Description

technical field [0001] The present invention relates to sensing systems and methods allowing the optical detection of said substances in fluids, in particular in biological fluids (e.g. blood, serum, plasma, saliva, urine) by using reagents which Reactive such that the reagent gives a specific optical response upon a defined optical stimulus or chemical reaction. The detection of those substances can be used for different purposes, such as the measurement of chemical substances in fluids and / or healthcare diagnosis in the event that those substances can be associated with a particular disease or other problem. This type of detection can be particularly useful for identifying the concentration of small substances in biological samples. Background technique [0002] From the various available techniques capable of detecting particles in fluids, it is known to use fluorescent or chemiluminescent agents in biological samples, which are able to produce or alter a fluorescent or ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/64G01N21/76G01N33/543G01N21/552
CPCG01N21/552G01N33/54326G01N21/76G01N33/54373G01N21/648
Inventor J·H·M·雷正J·H·尼乌文赫伊斯A·R·范多恩M·伊姆舍尔
Owner МИНИКЭАР Б.В.