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Imaging systems and methods for tissue differentiation, e.g., for intraoperative visualization

A lymphatic system and probe technology, applied in the field of multi-channel real-time and visual distinction, can solve the problems of incorrect cutting, nerve damage, non-existence, etc., and achieve the effect of maintaining sensitivity, reducing lymphedema, and high sensitivity

Inactive Publication Date: 2018-09-04
MEMORIAL SLOAN KETTERING CANCER CENT +1
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Problems solved by technology

However, no technique exists that readily provides visual differentiation between different neurons
Surgeons have difficulty seeing nerve tissue during surgery, and improperly cutting or damaging nerves during surgery can have lifelong adverse effects on patients

Method used

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  • Imaging systems and methods for tissue differentiation, e.g., for intraoperative visualization
  • Imaging systems and methods for tissue differentiation, e.g., for intraoperative visualization
  • Imaging systems and methods for tissue differentiation, e.g., for intraoperative visualization

Examples

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example

[0170] Conjugation of peptides to the C' point for visual differentiation of neural tissue during surgical procedures

[0171] The peptide used in this example is 17AANP41, which includes the core sequence NTQTLAKAPEHT (SEQ ID NO: 3). However, this example is not limited to the 17AA neural binding peptides provided. For example, other peptides (e.g., anti-parathyroid hormone (PTH) and GATA antibodies (e.g., GATA1 antibodies, such as GATA2 antibodies, such as GATA3 antibodies, such as GATA4 antibodies, such as GATA5 antibodies), such as ChAT , such as anti-CGRP), as described herein.

[0172] Choline acetyltransferase (ChAT), an enzyme that catalyzes the formation of acetylcholine, is overexpressed in motor nerves such as the facial nerve. Choline acetyltransferase therefore serves as an attractive target for motor neurons.

[0173] Choline acetyltransferase

[0174] Commercially available anti-ChAT antibody fragments (eg, scFv or Fab) were used as ligands for generating C'...

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Abstract

Described herein is a multiplex platform that uses ultrasmall nanoparticles (e.g., C dots and C' dots) to graphically differentiate specific nerves (e.g., sensory nerves vs. motor nerves) for nerve transplants and other surgeries. Also described herein is a multiplex platform that uses ultrasmall nanoparticles (e.g., C dots and C' dots) to graphically differentiate between different types of lymphnodes and / or lymphatic pathways, e.g., to safely and effectively perform vascularized lymph node transplantation in the treatment of lymphedema. Also described herein is a multiplex platform that uses ultrasmall nanoparticles (e.g., C dots and C' dots) to graphically differentiate parathyroid tissue.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Application No. 62 / 267,676, filed December 15, 2015, and U.S. Provisional Application No. 62 / 349,538, filed June 13, 2016, the entire contents of which are incorporated by reference This article. [0003] governmental support [0004] This invention was made with government support under Contract No. CA199081 awarded by the National Institutes of Health. The government has certain rights in this invention. [0005] sequence listing [0006] This description refers to the sequence listing (submitted electronically as a .txt file named "SEQUENCELISTING 2003080-1277.txt" on December 15, 2016). The .txt file was generated on December 13, 2016 and its size is 1.75 kilobytes. The entire contents of the Sequence Listing are incorporated herein by reference. technical field [0007] The present invention generally relates to methods for graphically differentiatin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61K51/12
CPCA61K49/0002A61K49/0032A61K49/0056A61K49/0058A61K49/0067A61K49/0093A61K51/1244A61B90/39A61B2090/392A61B5/0071A61B5/413A61B5/418A61B5/743A61K51/082A61M5/007A61M2005/006
Inventor M·S·布拉德伯里巴内·游乌尔里希·维斯纳陈培明马凯S·G·帕特尔达尼埃拉·卡拉萨瓦·扎诺尼J·达扬N·R·阿布-拉斯特姆
Owner MEMORIAL SLOAN KETTERING CANCER CENT
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