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Gamithromycin pharmaceutical composition and applications thereof

A technology of gamiomycin and a composition, which is applied in the field of gamiycin compositions, can solve the problems of narrow antibacterial spectrum, high labor intensity for injection administration, poor treatment effect, etc., and achieves strong antibacterial activity and reduced resistance The production of medicinal bacteria, the effect of good therapeutic effect

Inactive Publication Date: 2018-09-25
LUOYANG HUIZHONG ANIMAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the early macrolide antibiotics mainly have the following defects: the antibacterial spectrum is narrow, and there are many Gram-negative bacilli that cannot effectively pass through the outer membrane of the bacteria due to macrolide antibiotics, so the treatment effect is not good
[0007] The development and application of a new type of animal-specific antibiotic gamimycin injection has better solved the problems caused by livestock and poultry respiratory diseases to the breeding industry. It is very large, which limits its application. The market urgently needs a drug that can maintain a long-term effect and is suitable for group administration. Therefore, it is necessary to develop a gamithromycin oral solution, soluble powder or granules

Method used

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  • Gamithromycin pharmaceutical composition and applications thereof
  • Gamithromycin pharmaceutical composition and applications thereof
  • Gamithromycin pharmaceutical composition and applications thereof

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Embodiment approach

[0017] As an embodiment of the present invention, the complexing agent is selected from one or more of sodium ethylenediaminetetraacetic acid, sodium calcium salt of ethylenediaminetetraacetic acid, and sodium 2-cyclohexanediaminetetraacetic acid.

[0018] As an embodiment of the present invention, the stabilizer is selected from inorganic acids or organic acids, preferably one or more of hydrochloric acid, sulfuric acid, phosphoric acid, nitric acid, citric acid, tartaric acid, and trifluoroacetic acid.

[0019] The invention relates to a gamimycin soluble powder, which comprises: 0%-40% of gaminomycin soluble salt, 0-30% of cosolvent, 0-30% of stabilizer, and the balance and when the content of the co-solvent is 0, the content of the stabilizer is not less than 10%; when the content of the stabilizer is 0, the content of the co-solvent is not less than 5%.

[0020] As an embodiment of the present invention, the gaminomycin composition is gaminomycin soluble powder, comprisin...

Embodiment 1

[0034] The preparation of embodiment 1 gamimycin solution

[0035] Including the following components in parts by weight:

[0036] Gamithromycin Tartrate 15%

[0037] Tween-80 5%

[0038] Sodium edetate 4%

[0039] Citric acid 2%

[0040] Dilute to 100ml with water for injection.

[0041] The specific operation steps are:

[0042] Add 15 g of gaminomycin tartrate (calculated as gaminomycin) into 80 ml of water for injection, stir to dissolve, add 5 g of Tween-80, stir evenly, add 2 g of precisely weighed citric acid, and stir evenly. Add appropriate amount of water to make up to 100ml.

Embodiment 2

[0043] The preparation of embodiment 2 Gamithromycin solution

[0044] Including the following components in parts by weight:

[0045] Gamithromycin Fumarate 15%

[0046] Span-80 5%

[0047] Sodium EDTA 5%

[0048] Phosphoric acid 1%

[0049] Dilute to 100ml with water for injection.

[0050] Other embodiments of gamithromycin solution include the following components in parts by weight in Table 1:

[0051] Other examples of table 1 Gamithromycin solution

[0052]

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Abstract

The present invention relates to a gamithromycin composition, which comprises 1-40% of a gamithromycin soluble salt, and other solubilizing components. According to the present invention, the gamithromycin composition can be administered orally so as to reduce the labor intensity of drug application, can reduce antibiotic consumption, and further has high treatment effect, wherein the cure rate ofthe gamithromycin composition is 5-15% higher than the cure rate of the similar products.

Description

technical field [0001] The invention relates to a composition and application of gamithromycin, belonging to the field of veterinary medicine. Background technique [0002] Porcine respiratory disease is a common and frequently-occurring disease in large-scale pig farms in my country. It occurs all year round, especially when the seasons alternate. The incidence rate of some pig farms is as high as 40%-80%, and the direct mortality rate can reach 20%. . It is very harmful, not only causing the direct death of pigs, but also causing slow weight gain of pigs, delay in slaughtering and other phenomena. There are many pathogenic microorganisms that cause porcine respiratory diseases, including bacterial pathogens, mainly Mycoplasma pneumoniae, Bordetella bronchis, Actinobacillus, Pasteurella multocida, Haemophilus parasuis, Streptococcus, Salmonella, Erythrocytes and Toxoplasma etc. These pathogens will cause damage to the lung tissue, and if they exist to varying degrees in p...

Claims

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Application Information

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IPC IPC(8): A61K31/7052A61K9/08A61K9/14A61K9/16A61K47/26A61K47/12A61K47/38A61K47/36A61P11/00A61P31/04
CPCA61K9/08A61K9/145A61K9/1652A61K31/7052A61K47/26Y02A40/70
Inventor 张许科周德刚
Owner LUOYANG HUIZHONG ANIMAL MEDICINE
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