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Citicoline injection pharmaceutical composition as well as preparation method and application thereof

A technology of citicoline and its composition, which is applied in the field of citicoline injection pharmaceutical composition and its preparation, can solve various diseases prone to hypertension, diabetes, heart disease, cerebral infarction, Problems such as high cost of use

Inactive Publication Date: 2018-09-28
JILIN BAINIAN HANKE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The problem that aging faces at the same time is the health of the elderly. With the increase of age, the body function of the elderly is gradually declining, and they are prone to various diseases such as high blood pressure, diabetes, heart disease, cerebral infarction, etc. Chronic diseases; for brain diseases, citicoline is currently one of the main drugs for the treatment of consciousness and limb behavior disorders caused by acute central nervous injury after surgery, and has a good therapeutic effect, but currently citicoline The preparations of choline drugs are mainly western medicine preparations, and the cost of use is relatively high. If some citicoline drugs combining Chinese and Western medicines can be developed, it will have broad market prospects and promotional significance

Method used

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  • Citicoline injection pharmaceutical composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A citicoline injection pharmaceutical composition, comprising the following raw materials in parts by weight: 250 parts of citicoline, 100 parts of docosahexaenoic acid (DHA), 200 parts of soybean oil for injection, 60 parts of lecithin for injection, 20 parts of glycerin for injection, 10 parts of sodium chloride, and 900 parts of water for injection.

[0023] A preparation method of the citicoline injection pharmaceutical composition described above, comprising the following steps:

[0024] S1. Take an appropriate amount of water for injection and add an appropriate amount of citicoline to dissolve, then add about 0.08% activated carbon, stir at 120 rpm for 30 minutes, and decolorize by back filtration for 25 minutes to obtain a citicoline solution;

[0025] S2. Weigh glycerin for injection and sodium chloride in proportion, dissolve in water for injection, and obtain the water phase;

[0026] S3. Weighing docosahexaenoic acid and lecithin for injection in proportion...

Embodiment 2

[0032] A citicoline injection pharmaceutical composition, comprising the following raw materials in parts by weight: 350 parts of citicoline, 150 parts of docosahexaenoic acid (DHA), 250 parts of soybean oil for injection, 130 parts of lecithin for injection, 30 parts of glycerin for injection, 15 parts of sodium chloride, and 1200 parts of water for injection.

[0033] A preparation method of the citicoline injection pharmaceutical composition described above, comprising the following steps:

[0034] S1. Take an appropriate amount of water for injection and add an appropriate amount of citicoline to dissolve, then add about 0.1% activated carbon, stir at 150 rpm for 40 minutes, and filter back to decolorize for 40 minutes to obtain a citicoline solution;

[0035] S2. Weigh glycerin for injection and sodium chloride in proportion, dissolve in water for injection, and obtain the water phase;

[0036] S3. Weighing docosahexaenoic acid and lecithin for injection in proportion, a...

Embodiment 3

[0042] A citicoline injection pharmaceutical composition, comprising the following raw materials in parts by weight: 400 parts of citicoline, 200 parts of docosahexaenoic acid (DHA), 350 parts of soybean oil for injection, 170 parts of lecithin for injection, 50 parts of glycerin for injection, 15 parts of sodium chloride, and 1400 parts of water for injection.

[0043] A preparation method of the citicoline injection pharmaceutical composition described above, comprising the following steps:

[0044] S1. Take an appropriate amount of water for injection and add an appropriate amount of citicoline to dissolve, then add about 0.12% activated carbon, stir at 170 rpm for 60 minutes, and filter back to decolorize for 55 minutes to obtain a citicoline solution;

[0045] S2. Weigh glycerin for injection and sodium chloride in proportion, dissolve in water for injection, and obtain the water phase;

[0046] S3. Weighing docosahexaenoic acid and lecithin for injection in proportion, ...

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Abstract

The invention specifically discloses a citicoline injection pharmaceutical composition as well as a preparation method and the application thereof. The pharmaceutical composition comprises the following raw materials in parts by weight: 200-500 parts of citicoline, 50-250 parts of docosahexaenoic acid (DHA), 100-400 parts of soybean oil for injection, 50-200 parts of lecithin for injection, 10-60parts of glycerin for injection, 5-20 parts of sodium chloride and 800-1500 parts of water for injection. The combined effect of citicoline and docosahexaenoic acid is better than that of the single use of citicoline and some commercially available medicines for treating impaired nerve functions, and the combination of the citicoline and docosahexaenoic acid is capable of enhancing the recovery capability and treatment effect of limb dysfunction caused by spinal cord damage of mice.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a citicoline injection pharmaceutical composition and a preparation method and application thereof. Background technique [0002] With the rapid development of the economy, the population structure of our country has also undergone major changes, and the aging of the population is a relatively obvious trend. It is estimated that by 2050, China's elderly population will reach 480 million, accounting for about two-fifths of the elderly population in Asia and one-quarter of the global elderly population, which is larger than the combined population of the United States, Britain, and Germany. The above data show that my country has entered an aging society ahead of schedule, and taking care of the elderly and allowing them to live a happy old age has become an important issue in our society. [0003] The problem that aging faces at the same time is the health of the elderly. With...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/7068A61K31/202A61K47/44A61K47/24A61P25/00A61P25/28
CPCA61K9/0019A61K9/107A61K31/202A61K31/7068A61K47/24A61K47/44A61P25/00A61P25/28A61K2300/00
Inventor 费青张丹张恒张戈
Owner JILIN BAINIAN HANKE PHARM CO LTD
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