Peritoneal dialysis systems and methods

A peritoneal dialysis, peritoneal space technology, applied in the field of peritoneal dialysis systems and methods, can solve the problems of restricted activities, weight gain of PD patients, complicated blood sugar control and the like

Inactive Publication Date: 2018-09-28
COOK MEDICAL TECH LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Use of glucose-based PD fluids complicates glycemic control in diabetics and contributes to weight gain in nearly all PD patients
[0011] The complexity of the PD system, while moderate, can be intimidating for some patients and supporters
[0012] During APD, the patient is restrained to a cumbersome machine that limits movement

Method used

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  • Peritoneal dialysis systems and methods
  • Peritoneal dialysis systems and methods

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Experimental program
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Embodiment approach 1

[0057] Embodiment 1. A method of peritoneal dialysis comprising:

[0058] (i) removing peritoneal dialysis ultrafiltrate, which contains osmotic agent, water, and nitrogenous waste products of the patient's metabolism, from the patient's peritoneal space;

[0059] (ii) filtering particles in the peritoneal dialysis ultrafiltrate to form pre-filtered peritoneal dialysis ultrafiltrate;

[0060] (iii) passing the pre-filtered peritoneal dialysis ultrafiltrate through a first filter to form a first retentate comprising an amount of osmotic agent and a first permeate comprising water and nitrogenous waste from the patient;

[0061] (iv) passing the first permeate through a second filter to form a second retentate containing nitrogenous waste from the patient and an aqueous second permeate;

[0062] (vi) combining at least a portion of the water contained in the second permeate with the first retentate to form a regenerated peritoneal dialysis medium comprising an amount of osmotic...

Embodiment approach 2

[0064] Embodiment 2: The peritoneal dialysis method according to embodiment 1, wherein:

[0065] During each of said filtering particles, said passing pre-filtered peritoneal dialysis ultrafiltrate, said passing first permeate, said combining and said returning, said first filter and said second The filter is housed in a dialysis unit housing that is carried on the patient.

Embodiment approach 3

[0066] Embodiment 3. The peritoneal dialysis method according to embodiment 1 or 2, wherein:

[0067] The removing includes a first pumping of the ultrafiltrate through a lumen of a catheter having a distal catheter region positioned in the patient's peritoneal space;

[0068] said filtering particles comprises a second pumping of ultrafiltrate through a lumen having an in-line filter;

[0069] said first filter has a molecular weight cut-off ranging from about 5 to about 15 kDa; and

[0070] The returning includes a third pumping of the regenerated peritoneal dialysis medium through the lumen of the catheter having a distal region located in the patient's peritoneal space.

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Abstract

Described are peritoneal, dialysis systems and methods that involve the use of first and second stage filtration of a used dialysate withdrawn from the peritoneal space of a patient. The first filtration stage forms a first retentate containing an osmotic agent and a first permeate containing water and nitrogen-containing waste products of the patient. The second filtration stage acts on the firstpermeate to form a second retentate containing nitrogen-containing waste products of the patient and a second permeate containing water. At least some of the water from the second permeate is combined with the first, retentate to form a regenerated peritoneal dialysis medium containing an amount of the osmotic agent. The regenerated peritoneal dialysis medium can be returned to the peritoneal space of the patient.

Description

[0001] Refer to related applications [0002] This application claims the benefit of priority to US Provisional Patent Application Serial No. 62 / 167,809, filed May 28, 2015, which is hereby incorporated by reference in its entirety. Background technique [0003] For patients with chronic kidney disease requiring renal replacement therapy, peritoneal dialysis (PD) has demonstrated significant advantages over hemodialysis. These advantages include lower overall costs, fewer hospitalizations, and lower patient mortality. In addition, peritoneal dialysis methods have become relatively simple, and most patients can learn the necessary skills. PD allows patients greater flexibility in planning when to go on dialysis. [0004] Most patients undergoing PD are treated with automated peritoneal dialysis (APD). APD is a regimen of daily (usually nightly) therapy using an automated pump. Typically, multiple fill-drain cycles are programmed into the machine and performed automatically ...

Claims

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Application Information

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IPC IPC(8): A61M1/28A61M1/16
CPCA61M1/28A61M1/1678A61M2205/50A61M1/1672A61M1/1696A61M1/287A61M2205/8206
Inventor D·布拉特尔K·哈恩A·伊施K·米尔纳
Owner COOK MEDICAL TECH LLC
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