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Integrated plasma separated HBV immunity adsorber

A hepatitis B virus and plasma separation technology, applied in the field of medical devices, can solve the problems of increasing patient treatment costs, incomplete use of adsorbents, and inability to achieve adsorption, etc., to reduce treatment costs, blood volume, and consumables costs Effect

Inactive Publication Date: 2018-10-02
WUHAN RUIFA MEDICAL DEVICES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing adsorbers cannot realize the cycle mode of "adsorption-regeneration-adsorption".
[0008] In addition, it should be pointed out that the adsorber disclosed in the patent with the publication number of CN 102631722 B is not divided into partitions, resulting in uneven adsorption of the fibrous adsorbent in the shell, resulting in unsatisfactory actual adsorption effect. Incomplete use of doses further increases patient treatment costs

Method used

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  • Integrated plasma separated HBV immunity adsorber
  • Integrated plasma separated HBV immunity adsorber
  • Integrated plasma separated HBV immunity adsorber

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] like figure 1 The shown one-piece plasma separation hepatitis B virus immunoadsorber includes a housing 1, a blood inlet 2, a blood outlet 3 and a plasma outlet 4 which are arranged on the housing 1 and communicate with the inside thereof, and the inner chamber of the housing 1 is provided with There are a separation chamber 5 and an adsorption chamber 6; the two ends of the inner cavity of the housing 1 are provided with a sealing ring 7; the separation chamber 5 is provided with a hollow fiber membrane 8; the two ends of the hollow fiber membrane 8 are inserted and fixed to the sealing ring 7 and communicated The blood inlet 2 and the blood outlet 3; the separation chamber 5 and the adsorption chamber 6 communicate through the first porous membrane 9 that only allows blood plasma to pass through; the adsorption chamber 6 is provided with a hepatitis B virus immunosorbent 10; the adsorption chamber 6 Connected with plasma outlet 4. The casing 1 is also provided with a...

Embodiment 2

[0030] like Figure 2-4The one-piece immunoadsorber for separating hepatitis B virus from plasma shown in this embodiment has the same main features as that of Embodiment 1, and the distinguishing feature is that the adsorption chamber 6 is also provided with a first adsorption chamber 14 and a first adsorption chamber 14. The second porous membrane 16 of the second adsorption chamber 15 that only allows the plasma in the blood to pass through, the second porous membrane 16 can allow the regeneration liquid 13 to pass through; Allowing plasma to permeate "means that only blood plasma is permeable in blood, and not only blood plasma is permeable in all substances (blood and others); the first adsorption chamber 14 communicates with the separation chamber 5 through the first porous membrane 9; The first adsorption cavity 14 is provided with a plurality of non-porous membranes 19 to separate it into a plurality of independent cavities 17, and each cavity 17 is provided with a wav...

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Abstract

The invention discloses an integrated plasma separated HBV immunity adsorber which comprises a shell, a blood inlet, a blood outlet and a plasma outlet. The blood inlet, the blood outlet and the plasma outlet are arranged on the shell and communicated with the inside of the same, a separation cavity and an adsorption cavity are arranged in an inner cavity of the shell, sealing rings are arranged at two ends of the inner cavity of the shell, a hollow fiber film is arranged in the separation cavity, and two ends of the hollow fiber film are fixed to the sealing rings in an inserted manner and communicated with the blood inlet and the blood outlet; the separation cavity and the adsorption cavity are communicated through a first porous film only allowing plasma to pass, and a HBV immunity adsorbent is arranged in the adsorption cavity. The integrated plasma separated HBV immunity adsorber has the advantages that by arranging the separation cavity and the adsorption cavity, synchronism of plasma separation and plasma adsorption can be realized, direct contact between blood cells and the adsorbent is avoided, and biocompatibility is improved; a regeneration treatment mode or a single-time adsorption treatment mode can be selected autonomously according to illness state of a patient; consumable cost and treatment cost are lowered, and adsorption effect is improved.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to an integrated immunoadsorber for separating hepatitis B virus from plasma. Background technique [0002] Hepatitis B virus immunoadsorbent is a filler of anti-hepatitis B virus antibody-carrier complex, which couples anti-hepatitis B virus antibody to the carrier matrix through the action of chemical bonds, and uses anti-hepatitis B virus antibody to Adsorption by Selective Binding of Human Hepatitis B Virus. Hepatitis B virus immunoadsorption therapy is a new technology developed in recent decades, mainly used for the treatment of hepatitis B. [0003] Compared with whole blood adsorption therapy, plasma adsorption therapy has less damage to blood cells and less impact on the internal environment of the human body, and has been widely used in the field of blood purification. The basic principle of plasma adsorption therapy is to introduce blood from the patient's body to the out...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/36
CPCA61M1/3679A61M2202/206A61M2202/0057
Inventor 张磊王业富胡定邦张媛温佳文何改粉韩玮
Owner WUHAN RUIFA MEDICAL DEVICES CO LTD
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