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Integrated plasma separating bilirubin adsorber

A plasma separation and bilirubin technology, applied in the field of medical devices, can solve problems such as incomplete use of adsorbents, increase patient treatment costs, and inability to achieve adsorption, and achieve the effects of reducing consumables costs, treatment costs, and blood volume.

Inactive Publication Date: 2018-07-17
WUHAN RUIFA MEDICAL DEVICES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the existing adsorbers cannot realize the cycle mode of "adsorption-regeneration-adsorption".
[0007] In addition, it should be pointed out that the adsorber disclosed in the patent with the publication number of CN 102631722B is not partitioned, resulting in uneven adsorption of the fibrous adsorbent in the shell, resulting in unsatisfactory actual adsorption effect. Incomplete use further increases patient treatment costs

Method used

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  • Integrated plasma separating bilirubin adsorber
  • Integrated plasma separating bilirubin adsorber
  • Integrated plasma separating bilirubin adsorber

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Such as figure 1 The shown integrated plasma separation bilirubin adsorber includes a housing 1, a blood inlet 2, a blood outlet 3 and a plasma outlet 4 that are arranged on the housing 1 and communicate with the interior thereof. The inner cavity of the housing 1 is provided with a separation Chamber 5 and adsorption chamber 6; both ends of the inner cavity of the housing 1 are provided with a sealing ring 7; the separation chamber 5 is provided with a hollow fiber membrane 8; the two ends of the hollow fiber membrane 8 are inserted and fixed on the sealing ring 7 and connected to the blood inlet 2 and the blood outlet 3; the separation chamber 5 and the adsorption chamber 6 communicate through the first porous membrane 9 that only allows plasma in the blood to pass through; the adsorption chamber 6 is provided with a bilirubin adsorbent 10; the adsorption chamber 6 is connected to the plasma outlet 4 connected. The casing 1 is also provided with a sample injection po...

Embodiment 2

[0029] Such as Figure 2-4The one-piece plasma separation bilirubin adsorber shown in this embodiment has the same main features as that of Embodiment 1, and the difference is that the adsorption chamber 6 is also provided with a first adsorption chamber 14 and a second adsorption chamber 6. The second porous membrane 16 of the adsorption chamber 15 that only allows the plasma in the blood to pass through, and the second porous membrane 16 can allow the regeneration liquid 13 to pass through; "Permeable" means that only plasma is permeable in blood, and not only plasma is permeable in all substances (blood and others); the first adsorption cavity 14 communicates with the separation cavity through the first porous membrane 9; the first adsorption The cavity 14 is provided with a plurality of non-porous membranes 19 to separate it into a plurality of independent cavities 17, and each cavity 17 is provided with a wavy linear adsorbent attachment film 18; Bilirubin adsorbent 10; ...

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Abstract

The invention discloses an integrated plasma separating bilirubin adsorber, comprising a shell, a blood inlet arranged on the shell and connected with the inner space, a blood outlet and a plasma outlet; the inner cavity of the shell is provided with a separation cavity and an adsorption cavity; sealing rings are arranged at both ends of the inner cavity of the shell; a hollow fiber membrane is arranged in the separation cavity, and two ends of the hollow fiber membrane are fixed into the sealing rings and connected with the blood inlet and the blood outlet; the separation cavity and the adsorption cavity are connected with a first perforated membrane with allowing plasma to pass through; and the adsorption cavity is equipped with bilirubin adsorbents. The integrated plasma separating bilirubin adsorber has the characteristics of setting the separation cavity and the adsorption cavity to separate the plasma and synchronize the plasma adsorption at the same time, avoiding the direct contact between the blood cells and the adsorbent and improving the biocompatibility; the regenerative treatment mode or single adsorption treatment mode is chosen independently according to the condition of the patients, reducing the cost of consumables and treatment and improving the adsorption effect.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to an integrated plasma separation bilirubin adsorber. Background technique [0002] The bilirubin adsorbent is an anion exchange resin, which has a positive charge with a basic group, and a negative charge with a carboxyl group in the bilirubin molecule. It is electrostatically adsorbed together to achieve specific adsorption of bilirubin. Bilirubin adsorbent is used to adsorb bilirubin and bile acid in plasma, and is suitable for the treatment of liver diseases such as fulminant hepatitis, postoperative liver failure, primary biliary cirrhosis and hyperbilirubinemia. At present, the plasma adsorption mode is adopted for the adsorption of bilirubin. [0003] At present, the bilirubin adsorption therapy in the prior art is that the blood first enters the plasma separator through the blood pump, and the plasma is separated from the blood cells through the sieving function of the plasm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/34A61M1/36
CPCA61M1/3496A61M1/3679
Inventor 张磊王业富胡定邦张媛温佳文何改粉韩玮
Owner WUHAN RUIFA MEDICAL DEVICES CO LTD
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