Unlock instant, AI-driven research and patent intelligence for your innovation.

Intracavity 3D printing trachea repairing device and trachea repairing method

A 3D printing, trachea technology, applied in the field of medical devices, can solve the problems of high survival rate, difficult to grow into blood vessels, increase the risk related to patients' surgery, etc., and achieve the effect of high failure rate

Active Publication Date: 2018-10-02
SHANGHAI PULMONARY HOSPITAL
View PDF8 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Tissue-engineered trachea is a kind of prosthesis, which is mechanically combined with related cells such as stem cells, so it is difficult to achieve a high survival rate
At the same time, there is no porous structure in the tissue-engineered prosthesis, which makes it difficult to grow into blood vessels
The prosthesis made by tissue engineering needs to be transplanted by surgery, which increases the risk of surgery for patients

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Intracavity 3D printing trachea repairing device and trachea repairing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 Intracavitary 3D printing tracheal repair device

[0035] Such as figure 1 The intracavity 3D printing tracheal repair device shown specifically includes: a main body 1 with a hollow blunt head at one end, the main body 1 of the device is cylindrical, and the material is stainless steel, and a working window 2 is provided on the main body 1; The fixing device 3 on the main body 1 on both sides of the working window 2; and various functional elements arranged in sequence at the opening of the working window 2, the functional elements include a positioning device 4, a scalpel 5, an image scanning device 6, a second A 3D printing device 7 , a second 3D printing device 8 and a crosslinking device 9 .

[0036] In the intracavity 3D printed tracheal repair device of this embodiment, the fixing device 3 is a tube-shaped device with blunt edges and has extensible blunt strip-shaped feet. The working window 2 is stretched after the position is determined. Used to anc...

Embodiment 2

[0040] Example 2 Using intracavitary 3D bioprinting technology to repair tracheal damage

[0041] (1) Preparation of cells, hydrogels, and high-temperature materials: chondrocytes were extracted from the body, subcultured, and digested with 3*10 6 / ml for resuspension; mix gelatin, cell suspension, and 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone in a ratio of 3:2:1 to make a hydrogel Mixed liquid; mix polylactic acid-glycolic acid copolymer and polyethylene glycol at a ratio of 3:1 to make a high-temperature stent material;

[0042] (2) Insertion: After anesthesia, insert the intracavitary 3D printed trachea repair device into the trachea, and adjust the working window to the position where the trachea is to be repaired;

[0043] (3) Ventilation: Connect the ventilation device to the ventilator to ensure the normal ventilation of the trachea during printing;

[0044] (4) Positioning: Use EBUS (transbronchial endoscopic ultrasonography) to scan, confirm that the area ...

Embodiment 3

[0048] Example 3 Using intraluminal 3D bioprinting technology to treat tracheal stenosis

[0049] (1) Preparation of cells, hydrogels, and high-temperature materials: chondrocytes were extracted from the body, subcultured, and digested with 3*10 6 / ml for resuspension; mix gelatin, cell suspension, and 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone in a ratio of 3:2:1 to make a hydrogel Mixed liquid; mix polylactic acid-glycolic acid copolymer and polyethylene glycol at a ratio of 3:1 to make a high-temperature stent material;

[0050] (2) Insertion: After anesthesia, insert the intracavity 3D printed trachea repair device into the trachea, and adjust the working window to the position to be repaired;

[0051] (3) Ventilation: Connect the ventilation device to the ventilator to ensure ventilation during printing;

[0052] (4) Positioning: EBUS (transbronchial endoscopic ultrasonography) scanning is used to confirm that the area to be repaired is within the working wind...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an intracavity 3D printing trachea repairing device and a trachea repairing method. The intracavity 3D printing trachea repairing device comprises a main body, fixing devices fixedly surrounding the main body on the two sides of a working window, a locating device, an operating scalpel, an image scanning device, a first 3D printing device, a second 3D printing device and acrosslinking device, wherein one end of the main body is a hollow blunt end, the working window is formed in the main body, and the locating device, the operation scalpel, the image scanning device, the first 3D printing device, the second 3D printing device and the crosslinking device are arranged in an opening of the working window. According to the adopted trachea repairing method, the integration of 3D printing is realized by adopting the intracavity 3D printing trachea repairing device, a biological material similar to a tissue-engineered trachea is printed, and the higher failure rate isavoided; in addition, a tissue like a vessel is also conveniently grown into the printing material due to a porous structure of the 3D printing material; and the intracavity printing is implemented through the integration of the 3D printing, and the defective trachea is repaired without operations.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to an intracavity 3D printed trachea repair device and a trachea repair method. Background technique [0002] At present, tracheal injury and repair are hot issues in the field of regenerative medicine. After resection of tracheal stenosis or benign tracheal disease, the length of the trachea is reduced. When the extent of tracheal damage is less than 6 cm, the resection of a section of trachea will not affect the end-to-end anastomosis. When the damage to the trachea is too large, the normal trachea cannot be docked safely. Therefore, excessive tracheal injury requires methods other than resection. There are several methods of tracheal repair. Autologous tissue transplantation has no immune rejection and can repair large-scale defected trachea, but there are many complications such as stenosis and collapse. Biocompatible prosthesis transplantation is a relatively new t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C12M3/00B33Y30/00A61F2/04
CPCA61F2/04C12M33/00B33Y30/00A61F2002/043
Inventor 王龙
Owner SHANGHAI PULMONARY HOSPITAL