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Biodegradable tracer material and its preparation method and application

A tracking material and biological technology, applied in the field of medical materials, can solve the problems of slow degradation rate of L-polylactic acid material, unsatisfactory degradation rate, limitation of positioning and tracking, etc., achieve rapid degradation in vivo and in vitro, and improve PLLA biological material. , the effect of shortening the degradation time

Active Publication Date: 2021-03-30
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The product has a fast quenching time after implantation in vivo, and its localization and tracking are limited
[0007] From the point of view of the current polymer degradable scaffolds, the positioning and tracking are limited, and the degradation rate of the L-lactic acid material is too slow, the degradation rate cannot meet the needs of the application, and the autophagy reaction caused by the implantation of the scaffold material And the restenosis of the blood vessel after the stent is introduced, which limits the scope of use of the material

Method used

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  • Biodegradable tracer material and its preparation method and application
  • Biodegradable tracer material and its preparation method and application
  • Biodegradable tracer material and its preparation method and application

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0050] Preparation of embodiment 1 biodegradable tracer material

[0051] The mass ratio of PLLA to TPE is 2.5mg: 0.05mg (100:2);

[0052] See figure 1 , Mix PLLA and TPE with chloroform thoroughly according to the above quality, and the mixing time must be guaranteed to be ≥ 3 days, so that PLLA and TPE are completely dissolved respectively, and during the TPE dissolution process, try to keep the light-proof environment. The dissolution temperature can be kept at a stable room temperature; the mixed solution of the two substances obtained is mixed and then fully stirred and dissolved. During the dissolution process, the environment is still protected from light and the temperature is maintained at room temperature. The two substances PLLA and TPE During the mixing process, it is necessary to ensure that the generation of bubbles is reduced, and it must be fully mixed to effectively make the substance form a uniform mixture, and to enable the PLLA molecular chain to wrap the ...

Embodiment 2

[0053] Preparation of embodiment 2 biodegradable tracer material

[0054] The mass ratio of PLLA to TPE is 2mg: 0.025mg (80:1);

[0055] The preparation method refers to Example 1.

Embodiment 3

[0056] Preparation of embodiment 3 biodegradable tracer material

[0057] The mass ratio of PLLA to TPE is 3mg: 0.125mg (120:5);

[0058] The preparation method refers to Example 1.

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Abstract

The invention belongs to the field of medical materials and particularly relates to a biodegradable tracing material prepared from PLLA (poly-l-lactic acid) and TPE (tetraphenyl ethylene), having a mass ratio of (80-120):(1-5); PLLA has a molecular weight of 600000 to 1000000. The biodegradable tracing material prepared from PLLA and TPE has co-aggregation lighting effect; PLLA acts as a high-biosafety material, TPE degrades with degradation of PLLA during in-vivo degradation so that fluorescence quenching occurs, the quenching speed matches with PLLA degrading speed, and material positioningand tracing can be better achieved. The biodegradable tracing material as a medical instrument implant has better in-vivo slow release and degrading effects, and the series of positioning and visual tracking issues due to long-term slow degradation are eliminated.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a biodegradable tracer material and its preparation method and application. Background technique [0002] Biodegradable and absorbable materials have been researched in the field of biomedicine for more than 40 years. The principle of application of biodegradable materials in the medical field is to decompose macromolecules through hydrolysis and enzymolysis under the physiological conditions of the body. Substances are degraded into small molecular substances that are not harmful to the body, or small molecular substances are degraded by themselves in the organism, and finally completely absorbed and excreted through the body's metabolism without causing toxic side effects to the body. Biodegradable materials have been widely used in surgical sutures, artificial skin, bone fixation materials, and drug release agents in vivo. [0003] The most common biomaterials mai...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00A61L17/10A61L17/12A61L31/04A61L31/14
CPCA61K49/0019A61K49/0054A61L17/10A61L17/12A61L31/041A61L31/14A61L31/148C08L67/04C08L25/02
Inventor 王贵学罗力吴伟尹铁英刘元莉王溢
Owner CHONGQING UNIV