Triazole-diazepine-5-ketone compound

A technology of ketone compounds and diazepines, which is applied in the field of medicine and can solve problems that have not been reported
CN108640922AActive Publication Date: 2018-10-12SHENYANG PHARMA UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHENYANG PHARMA UNIVERSITY
Publication Date
2018-10-12

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Abstract

The invention belongs to the technical field of drugs, and relates to a triazole-diazepine-5-ketone compound and application thereof, in particular to application of the compound, which serves as a tumor cell proliferation inhibitor, in the aspect of preparing antineoplastic drugs. According to the compound, the pharmaceutically accepted salt, solvate or isomer thereof has a structural formula asshown in the description, wherein the definitions of R1 to R8 are as described in the claims and the description.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and relates to a triazolodiazepin-5-one compound and its application, specifically, relates to the use of this type of compound as a tumor cell proliferation inhibitor in the preparation of antitumor drugs application. Background technique

[0002] Malignant tumor is a serious disease that threatens human health and life, and it is the leading cause of death in China. Searching for and discovering new drugs for the treatment and prevention of tumors is a major issue at present. 4-Substituted methoxybenzoyl-aryl-thiazole (SMART) is a tubulin polymerization inhibitor obtained by structural optimization of natural products as lead compounds. It exerts its anticancer activity by acting on the colchicine binding site to inhibit tubulin polymerization , and it can overcome the problem of Pgp-mediated multidrug resistance, and has lower neurotoxicity compared with vinblastine. The in vivo efficacy o...

Claims

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