A kind of hyaluronic acid prodrug and its preparation method and application in transdermal administration
A technology of hyaluronic acid and prodrugs, applied in the field of hyaluronic acid prodrugs and its preparation, can solve the problems of carrier biocompatibility to be improved, skin irritation and allergies, normal skin barrier function damage, etc. Achieve the effects of improving percutaneous permeability, facilitating treatment, and improving targeting
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Embodiment 1
[0037] Embodiment 1: Preparation of hyaluronic acid grafted 5-aminolevulinic acid
[0038] (1) Weigh the corresponding raw materials: hyaluronic acid, drug molecule, N-hydroxysuccinimide, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, water residue quantity;
[0039] The mass ratio of described hyaluronic acid and drug molecule is 10:1, and hyaluronic acid, N-hydroxysuccinimide and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide salt The mass ratio of acid salt is: 4:2:1;
[0040] (2) Dissolve hyaluronic acid in water, then add N-hydroxysuccinimide and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, and place on a magnetic stirrer on, stirring at a speed of 200r / min for 1h;
[0041] (3) Dissolve the drug molecule in water, then add it into (2), and stir overnight; put the obtained sample into a dialysis bag (molecular weight cut-off is 500), and then immerse the dialysis bag in pure water and stir for 3 days , freeze-dried to obtain hyaluronic acid...
Embodiment 2
[0043] Embodiment 2: Preparation of hyaluronic acid grafted 5-aminolevulinic acid
[0044] (1) Weigh the corresponding raw materials: hyaluronic acid, drug molecule, N-hydroxysuccinimide, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, water residue quantity.
[0045] The mass ratio of hyaluronic acid to drug molecules is 5:1, hyaluronic acid, N-hydroxysuccinimide and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide salt The mass ratio of acid salt is: 4:2:1;
[0046] (2) Dissolve hyaluronic acid in water, then add N-hydroxysuccinimide and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, and place on a magnetic stirrer on, stirring at a speed of 200r / min for 1h;
[0047] (3) Dissolve the drug molecule in water, then add it into (2), and stir overnight; put the obtained sample into a dialysis bag (molecular weight cut-off is 500), and then immerse the dialysis bag in pure water and stir for 3 days , freeze-dried to obtain hyaluronic acid grafted with 5-a...
Embodiment 3
[0049] Embodiment 3: Preparation of hyaluronic acid grafted 5-aminolevulinic acid
[0050] (1) Weigh the corresponding raw materials: hyaluronic acid, drug molecule, N-hydroxysuccinimide, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, water residue quantity.
[0051] The mass ratio of the hyaluronic acid to the drug molecule is 2:1, and the hyaluronic acid, N-hydroxysuccinimide and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide salt The mass ratio of acid salt is: 4:2:1;
[0052] (2) Dissolve hyaluronic acid in water, then add N-hydroxysuccinimide and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, and place on a magnetic stirrer on, stirring at a speed of 200r / min for 1h;
[0053] (3) Dissolve the drug molecule in water, then add it into (2), and stir overnight; put the obtained sample into a dialysis bag (molecular weight cut-off is 500), and then immerse the dialysis bag in pure water and stir for 3 days , freeze-dried to obtain hyaluronic acid...
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