Compound for preventing and treating renal injury
A compound and kidney injury technology, which can be used in drug combinations, medical preparations containing active ingredients, cardiovascular system diseases, etc., can solve the problem of lack of effective treatment drugs for kidney injury, achieve the effect of reducing creatinine value and improving pathological manifestations
Active Publication Date: 2018-10-23
WEST CHINA HOSPITAL SICHUAN UNIV
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Problems solved by technology
[0005] The object of the present invention is to provide compounds for preventing and treating kidney damage, so as to solve the problem of lack of effective drugs for treating kidney damage in the prior art
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Embodiment 1
[0047] Therapeutic effect of embodiment 1 compound of the present invention on renal injury
[0048] 1. Mouse model of ischemia-reperfusion acute kidney injury
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The invention relates to a compound for preventing and treating renal injury, and belongs to the field of medicine, and solves the technical problem of lack of an effective therapeutic drug for the renal injury in the prior art. The technical proposal provides use of a compound of the formula I, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable ester thereof in preparingdrugs for prevention and treatment of the renal injury. Experimental results show that the compound has an exact therapeutic effect on the renal injury, can significantly improve the pathological manifestations of damaged renal tissues, reduces renal injury score and creatinine level, and provides a new drug selection for clinical prevention and treatment of the renal injury.
Description
technical field [0001] The invention relates to a compound for preventing and treating kidney damage, and belongs to the field of medicine. Background technique [0002] Kidney injury is a common medical nephropathy syndrome. The pathological manifestations are renal tubular epithelial cell death, brush border disappearance, tubular obstruction, and endothelial cell injury. It can lead to multiple organ failure and is a critical illness with a high risk of death. At present, it is believed that the pathophysiological mechanism of the pathogenesis and progression of renal injury includes oxidative stress response, endoplasmic reticulum stress response, autoimmune response, etc., immune inflammation, ischemia, oxidative stress, poisoning, and autoimmunity are interconnected, promoting or Restriction, forming a very complex network relationship, involved in the formation and progression of renal injury in many ways. [0003] The treatment of renal injury is mainly based on sup...
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IPC IPC(8): A61K31/415A61P13/12A61P9/10A61P43/00
CPCA61K31/415A61P9/10A61P13/12A61P43/00
Inventor 马良石敏杜晓艳郭帆付平
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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