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A kind of pea protein-curcumin nanocomposite and its preparation method and application

A nano-composite, pea protein technology, applied in the directions of polymer compounds inactive ingredients, drug combinations, allergic diseases, etc., can solve problems such as difficulty in industrial production, poor emulsifier safety, and easy flocculation of wall materials. , to achieve mild reaction conditions, good stability and dispersion, and simple operation.

Active Publication Date: 2021-05-07
SHANGHAI OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this method has defects such as low curcumin content and poor emulsifier safety.
In addition, the microcapsule process can also improve the water solubility and storage stability of curcumin. However, because many wall materials are prone to flocculation, some curcumin microcapsules have formed precipitation during storage, making it difficult to Difficult to apply in industrial production (Ko et al., 2015; Liu, Chen, Cheng, & Selomulya, 2016; Paramera, Konteles, & Karathanos, 2011)
Therefore, there is currently no suitable method for stably dispersing curcumin

Method used

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  • A kind of pea protein-curcumin nanocomposite and its preparation method and application
  • A kind of pea protein-curcumin nanocomposite and its preparation method and application
  • A kind of pea protein-curcumin nanocomposite and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] (1) Purification (removal of impurities) of pea protein:

[0059] Weigh a certain amount of pea protein and disperse it in distilled water (the weight ratio of pea protein to distilled water is 3:100), then homogenize for 15 minutes under stirring conditions, and then use M-100P microfluidization to treat the above-mentioned samples. After processing, the pea protein emulsion was centrifuged at 1,000 rpm, and the suspension was collected and freeze-dried. The particle size of the purified pea protein nanoemulsion is 48.45nm, the Zeta-potential is -35mV, the polydispersity is 0.22, and the surface tension is 65.15mN / m.

[0060] (2) Optimizing the conditions for microfluidization treatment of pea protein-curcumin nanoemulsion:

[0061] Under the condition that the number of microfluidization cycles is 2 times and the ratio of pea protein (prepared in step (1)) to curcumin is 35:1 (w / w), different pressures (30, 60, 80, 120, 170 and 200MPa) for optimization. Depend on ...

Embodiment 2

[0071] (1) Purification (removal of impurities) of pea protein:

[0072] Weigh a certain amount of pea protein and disperse it in distilled water (the weight ratio of pea protein to distilled water is 4:100), then homogenize for 20 minutes under stirring conditions, and then use M-100P microfluidization to treat the above-mentioned samples. The processed pea protein emulsion was centrifuged at 1,200 rpm, and the suspension was collected and freeze-dried. The particle size of the purified pea protein nanoemulsion is 58.05nm, the Zeta-potential is -34.55mV, the polydispersity is 0.27, and the surface tension is 63.50mN / m.

[0073] (2) prepare the pea protein-curcumin nanocomposite that the ratio of pea protein and curcumin is 35:1:

[0074] Under optimal microfluidization conditions (pressure 200MPa, cycle number 2 times, temperature 4°C and stirring speed 800rpm), take pea protein (prepared in step (1)) and curcumin with a weight ratio of 35:1 The pea protein-curcumin nanocom...

Embodiment 3

[0082] (1) Purification (removal of impurities) of pea protein:

[0083] Weigh a certain amount of pea protein and disperse it in distilled water (the weight ratio of pea protein to distilled water is 5:100), then homogenize for 25 minutes under stirring conditions, and then use M-100P microfluidization to treat the above-mentioned samples. After processing, the pea protein emulsion was centrifuged at 1,000 rpm, and the suspension was collected and freeze-dried. The particle diameter of the purified pea protein nanoemulsion is 52.47nm, the Zeta-potential is -33.45mV, the polydispersity is 0.23, and the surface tension is 63.58mN / m.

[0084] (2) prepare the pea protein-curcumin nanocomposite that the ratio of pea protein and curcumin is 50:1:

[0085] Under optimal microfluidization conditions (pressure 200MPa, cycle number 2 times, temperature 4°C and stirring speed 900rpm), take pea protein (prepared in step (1)) and curcumin with a weight ratio of 50:1 The pea protein-curc...

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Abstract

The invention relates to a pea protein-curcumin nanocomposite, a preparation method and application thereof. The weight ratio of pea protein and curcumin in the complex is 25:1‑60:1. The preparation method comprises steps: (1) Weighing a certain amount of pea protein and dispersing it in distilled water or deionized water, homogenizing under stirring, then performing microfluidization treatment, and then centrifuging, collecting the suspension and freeze-drying the suspension to obtain pea Protein powder; (2) utilize described pea protein powder and curcumin to optimize the condition of microfluidization method, select optimum microfluidization condition; (3) according to the optimum microfluidization condition in step (2), utilize microfluidization A pea protein-curcumin nanocomposite emulsion was prepared by a fluidization method, and then the emulsion was freeze-dried to prepare a pea protein-curcumin nanocomposite powder. The complex can greatly improve the dispersion efficiency of curcumin and the concentration in the pea protein-curcumin nano-mixed emulsion, and can be used to prepare anti-tumor, immune regulation, anti-oxidation or anti-atherosclerotic drugs.

Description

technical field [0001] The invention relates to a soluble curcumin nanocomposite, more specifically to a pea protein-curcumin nanocomposite and its preparation method and application. Background technique [0002] Curcumin is a natural pigment extracted from turmeric. In recent years, curcumin has attracted widespread attention from scholars at home and abroad due to its anti-tumor, immune regulation, anti-oxidation and anti-atherosclerosis functions. However, curcumin has low bioavailability due to its poor water solubility, poor absorption in the body, and rapid metabolism. Curcumin is sensitive to light, heat, and acid environmental factors. Improving the storage stability of curcumin has always been the focus of attention in the food and medical industries. Traditional methods to improve the stability of curcumin mainly include solvent precipitation and microemulsion embedding. The solvent precipitation method is mainly to dissolve curcumin in organic solvents such as ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/42A61K31/12A61P35/00A61P37/02A61P39/06A61P9/10
CPCA61K31/12A61K47/42A61P9/10A61P35/00A61P37/02A61P39/06
Inventor 张洪才姜官鑫梅俊陈舜胜薛永霞
Owner SHANGHAI OCEAN UNIV
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