A kind of preparation method of drug-loaded gold nano dendrite particles
A gold nanoparticle and gold nanotechnology, which is applied in the field of preparation of drug-loaded gold nanodendrite particles, can solve the problems of gold nanomaterial temperature rise, tumor tissue killing, and no in-depth research, so as to achieve controllable release rate and increase The effect of drug loading
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Embodiment 1
[0024] In this embodiment, a preparation method of drug-loaded gold nanodendritic particles comprises the following steps in sequence:
[0025] (1) Preparation of spherical gold nanoparticle seeds: Add 0.5mL of 50mM tetrachloroauric acid aqueous solution to 50mL deionized water and boil for 5 minutes, then add 1mL of 30mM sodium citrate solution for reduction, and allow the mixture to react for 15 minutes , then cooled to room temperature, centrifuged at 11000 rpm for 30 min, and then dispersed into 50 mL of deionized water to obtain spherical gold nanoparticles.
[0026] (2) Growth of gold nanodendrites: 500 μL of spherical gold nanoparticles in step (1), 8 mL of 0.2 M oleylamine methanol solution, 500 μL of 150 mM chloroauric acid ethanol solution and 30 μL of 0.3 M vitamin C methanol solution was added into the reaction bottle for reaction, and then placed on a stirring shaker for about 10 minutes to 24 hours to generate hydrophobic gold nano dendrites.
[0027] (3) Phase ...
Embodiment 2
[0030] In this embodiment, a preparation method of drug-loaded gold nanodendritic particles comprises the following steps in sequence:
[0031] (1) Preparation of spherical gold nanoparticle seeds: the 50mM tetrachloroauric acid aqueous solution of 5mL was added to 50mL deionized water and boiled for 5 minutes, then added 20mL of 30mM sodium citrate solution for reduction, and the mixture was reacted for 15 minutes, Then cool to room temperature, centrifuge at 11000 rpm for 30 min, and then disperse into 50 mL of deionized water to obtain spherical gold nanoparticles.
[0032] (2) Growth of gold nanodendrites: In step (1), 10 μL of spherical gold nanoparticle seeds, 1 mL of oleylamine methanol solution with a concentration of 0.2 M, 20 μL of chloroauric acid ethanol solution with a concentration of 150 mM and 30 μL of a concentration of 0.3 The vitamin C methanol solution of M is added into the reaction flask for reaction, and then placed on a stirring shaker for about 10 minu...
Embodiment 3
[0036] In this embodiment, a preparation method of drug-loaded gold nanodendritic particles comprises the following steps in sequence:
[0037] (1) Preparation of spherical gold nanoparticle seeds: 2mL of 50mM tetrachloroauric acid aqueous solution was added to 50mL deionized water and boiled for 5 minutes, then added 8mL of 30mM sodium citrate solution for reduction, and the mixture was reacted for 15 minutes, Then cool to room temperature, centrifuge at 11000 rpm for 30 min, and then disperse into 50 mL of deionized water to obtain spherical gold nanoparticles.
[0038] (2) Growth of gold nanodendrites: 100 μL of spherical gold nanoparticle seeds in step (1), 2 mL of oleylamine methanol solution with a concentration of 0.2 M, 100 μL of chloroauric acid ethanol solution with a concentration of 150 mM and 30 μL of a concentration of 0.3 The vitamin C methanol solution of M is added into the reaction bottle for reaction, and then placed on a stirring shaker for about 10 minutes...
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