A kind of catalytic synthesis method of c-3 aryl selenoimidazopyridine compound
A technology of imidazopyridine and synthesis method, applied in the field of synthetic chemistry, can solve problems such as restricting large-scale industrial production of compounds, high temperature, and inability to recycle
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0042]
[0043] At room temperature, nano copper ferrite (0.02 mmol), 2-phenylimidazo[1,2-a]pyridine (0.2 mmol ), diphenyldiselenide (0.12 mmol), and 2 mL of anhydrous tetrahydrofuran were added under oxygen, and the tube was stirred in an oil bath, and reacted at 40 ° C for 24 h. The progress of the reaction was monitored by TLC (Thin Layer Chromatography). After the reaction was complete, the resulting solution was cooled to room temperature. The magnet is placed outside the reaction vessel, the catalyst is adsorbed on the wall of the reaction vessel by magnetic attraction, the reaction solution is poured into a separatory funnel, and 5 milliliters of ethyl acetate is poured into the reaction vessel, and the catalyst is washed twice. Pour ethyl acetate into the separatory funnel, then add 5 milliliters of water and 5 milliliters of ethyl acetate to the separatory funnel, extract the reaction solution, repeat the extraction 4 times, combine the organic phases and dry them...
Embodiment 2
[0047]
[0048] At room temperature, nano copper ferrite (0.03 mmol), 2-phenylimidazo[1,2-a]pyridine (0.2 mmol ), p-chlorodiphenyldiselenide (0.12 mmol), 2 mL of anhydrous THF was added under oxygen, the tube was placed in an oil bath and stirred, and reacted at 60 ° C for 16 h. The progress of the reaction was monitored by TLC (Thin Layer Chromatography). After the reaction was complete, the resulting solution was cooled to room temperature. The magnet is placed outside the reaction vessel, the catalyst is adsorbed on the wall of the reaction vessel by magnetic attraction, the reaction solution is poured into a separatory funnel, and 5 milliliters of ethyl acetate is poured into the reaction vessel, and the catalyst is washed twice. Pour ethyl acetate into the separatory funnel, then add 5 milliliters of water and 5 milliliters of ethyl acetate to the separatory funnel, extract the reaction solution, repeat the extraction 4 times, combine the organic phases and dry them w...
Embodiment 3
[0053]
[0054] At room temperature, nanometer copper ferrite (0.01 mmol), 2-phenylimidazo[1,2-a]pyridine (0.2 mmol ), p-bromodiphenyldiselenide (0.15 mmol), 2 mL of anhydrous THF was added under oxygen, the tube was placed in an oil bath and stirred, and reacted at 60 ° C for 24 h. The progress of the reaction was monitored by TLC (Thin Layer Chromatography). After the reaction was complete, the resulting solution was cooled to room temperature. The magnet is placed outside the reaction vessel, the catalyst is adsorbed on the wall of the reaction vessel by magnetic attraction, the reaction solution is poured into a separatory funnel, and 5 milliliters of ethyl acetate is poured into the reaction vessel, and the catalyst is washed twice. Pour ethyl acetate into the separatory funnel, then add 5 milliliters of water and 5 milliliters of ethyl acetate to the separatory funnel, extract the reaction solution, repeat the extraction 4 times, combine the organic phases and dry th...
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More