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Rapid detection method and device for sufentanil in plasma

A detection method, plasma technology, applied in the detection field of sufentanil, to achieve the effect of good signal enhancement and ideal signal enhancement

Active Publication Date: 2020-07-14
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no method for on-site detection of sufentanil in plasma by TLC-SERS technology

Method used

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  • Rapid detection method and device for sufentanil in plasma
  • Rapid detection method and device for sufentanil in plasma
  • Rapid detection method and device for sufentanil in plasma

Examples

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Embodiment Construction

[0023] The specific implementation of the present invention will be described below in conjunction with the examples. In the following examples, the Raman spectrometer used is a BWS415-785H portable Raman spectrometer with an excitation light source of 785nm and a resolution of 3.5cm -1 @912nm, spectral range 175-2700cm -1, equipped with BAC151 video microscope Raman detection system (eyepiece × 20); the thin-layer plate is a silica gel plate with a coating thickness of 0.2mm-0.25mm and a silica gel powder particle size (8±2)μm≧80%. In addition, the reagents used in the examples were obtained from general commercial sources unless otherwise specified, and the unspecified experimental conditions were referred to the conventional experimental conditions or followed the conditions suggested by the suppliers.

[0024]

[0025] 1. Reagent preparation and preparation

[0026] 1.1 Silver colloid preparation

[0027] The silver colloid adopted in the present embodiment contai...

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Abstract

The invention provides a quick detection method for sufentanil in blood plasma. The method comprises the following steps: S1, pre-treating to-be-tested blood plasma to obtain a to-be-tested plasma sample; S2, preparing a standard solution and a simulated blood plasma sample; S3, sucking the to-be-tested blood plasma sample, the simulated blood plasma sample and a standard solution separately and dispensing the same on a same silica gel board; S4, unfolding, airing and developing the to-be-tested blood plasma sample, the simulated blood plasma sample and the standard solution on the silica gelboard with an iodine cylinder; S5, separately dropwise adding a pre-amount silver gel to spots of sufentanil in the to-be-tested blood plasma sample and the simulated blood plasma sample; S6, carryingout surface-enhancement raman scattering detection on the spots where the silver gel is dropwise added; and S7, calculating sufentanil concentration in the to-be-tested blood plasma sample, wherein the suction amounts of the to-be-tested blood plasma sample, the simulated blood plasma sample and the standard solution in the S3 are 1 microL, the pre-amount of the silver gel in the S5 is 5 microL,and the silver gel comprises nano silver particles, the average grains of which are 50nm.

Description

technical field [0001] The invention relates to a detection method for sufentanil, in particular to a rapid detection method and device for sufentanil in blood plasma. Background technique [0002] Sufentanil is a fentanyl derivative with the chemical name N-[4-(methoxymethyl)-1-2[2-(2-thienyl)ethyl]-4-piperidine Base]-N-phenylpropanamide, its fat solubility is 1100 times that of morphine, it can easily pass through the blood-brain barrier, and can quickly reach an effective concentration in the brain, and its analgesic effect is about 5-10 times that of fentanyl. Morphine is 300-400 times that of opioid analgesics with the strongest analgesic effect at present. It is widely used in clinical anesthesia induction, intraoperative maintenance and postoperative analgesia. [0003] Sufentanil is suitable for anesthesia in various operations, but due to individual differences in patients, the dosage of sufentanil should be adjusted in time according to the patient's response to a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/90G01N21/65
CPCG01N21/658G01N30/90
Inventor 亓云鹏朱青霞张天吴泽兵陆峰
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY