The invention discloses a dynamic positioning method and device based on UWB and laser ranging combination and belongs to dynamic positioning methods and devices. The dynamic positioning device comprises an ultra-wide band (UWB) wireless communication sensors, a UWB positioning label, laser ranging sensors, an upper computer and a POE interchanger. An ultra-wide band (UWB) wireless communication sensor station is arranged in an area to be detected, the laser ranging sensors are installed on and fixed to the ultra-wide band (UWB) wireless communication sensors, the UWB positioning label is fixed to a target to be detected, and the ultra-wide band (UWB) wireless communication sensors and the laser ranging sensors are connected with the upper computer through the POE interchanger. According to the dynamic positioning method and device based on the UWB and laser ranging combination, the laser ranging sensors are arranged on the ultra-wide band (UWB) wireless communication sensors respectively, so that the relative distance between every two adjacent ultra-wide band (UWB) wireless communication sensors is obtained, in this way, the coordinates of the ultra-wide band (UWB) wireless communication sensors can be re-determined or corrected after the ultra-wide band (UWB) wireless communication sensors are moved, and thus the requirement for dynamic positioning is met. The dynamic positioning method and device based on the UWB and laser ranging combination have the advantages that the dynamic positioning method based on the UWB and laser ranging combination is adopted, positioning is accurate, safety and reliability are guaranteed, installation is easy, and operation is convenient.