Patents
Literature
Patsnap Copilot is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Patsnap Copilot

241results about How to "Accurate distance measurement" patented technology

Dynamic positioning method and device based on UWB and laser ranging combination

The invention discloses a dynamic positioning method and device based on UWB and laser ranging combination and belongs to dynamic positioning methods and devices. The dynamic positioning device comprises an ultra-wide band (UWB) wireless communication sensors, a UWB positioning label, laser ranging sensors, an upper computer and a POE interchanger. An ultra-wide band (UWB) wireless communication sensor station is arranged in an area to be detected, the laser ranging sensors are installed on and fixed to the ultra-wide band (UWB) wireless communication sensors, the UWB positioning label is fixed to a target to be detected, and the ultra-wide band (UWB) wireless communication sensors and the laser ranging sensors are connected with the upper computer through the POE interchanger. According to the dynamic positioning method and device based on the UWB and laser ranging combination, the laser ranging sensors are arranged on the ultra-wide band (UWB) wireless communication sensors respectively, so that the relative distance between every two adjacent ultra-wide band (UWB) wireless communication sensors is obtained, in this way, the coordinates of the ultra-wide band (UWB) wireless communication sensors can be re-determined or corrected after the ultra-wide band (UWB) wireless communication sensors are moved, and thus the requirement for dynamic positioning is met. The dynamic positioning method and device based on the UWB and laser ranging combination have the advantages that the dynamic positioning method based on the UWB and laser ranging combination is adopted, positioning is accurate, safety and reliability are guaranteed, installation is easy, and operation is convenient.
Owner:CHINA UNIV OF MINING & TECH

Consensus configurational bias Monte Carlo method and system for pharmacophore structure determination

InactiveUS6341256B1Accurate distance measurementMake a pharmacophore structure determinationPeptide librariesNanotechNMR - Nuclear magnetic resonancePeptide
In a specific embodiment, this invention includes a method for determining an accurate, consensus pharmacophore structure shared by compounds that bind selectively to a target molecule. Optionally, the method begins with screening a diversity library against the target molecule of interest to pick the selectively binding members. Next the structure of the selected members is examined and a candidate pharmacophore responsible for the binding to the target molecule is determined. Next, preferably by REDOR nuclear magnetic resonance, several highly accurate interatomic distances are determined in certain of the selected members which are related to the candidate pharmacophore. A highly accurate consensus, configurational bias, Monte Carlo method determination of the structure of the candidate pharmacophore is made using the structure of the selected members and incorporating as constraints the shared candidate pharmacophore and the several measured distances. This determination is adapted to efficiently examine only relatively low energy configurations while respecting any structural constraints present in the organic diversity library. If the diversity library contains short peptides, the determination respects the known degrees of freedom of peptides as well as any internal constraints, such as those imposed by disulfide bridges. Finally, the highly accurate pharmacophore so determined is used to select lead organics for drug development targeted at the initial target molecule.
Owner:CURAGEN CORP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products