Construction method of rat muscular fasciae trigger point model

A construction method and trigger point technology, applied in medical science, veterinary instruments, veterinary surgery, etc., can solve the problems of no recognized disease model and less research, and achieve good stability, high survival rate, and strong replicability Effect

Inactive Publication Date: 2018-11-06
SHANGHAI UNIV OF SPORT
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are still few studies on rats applied to myofascial trigger points, and there is no recognized and effective disease model

Method used

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  • Construction method of rat muscular fasciae trigger point model
  • Construction method of rat muscular fasciae trigger point model
  • Construction method of rat muscular fasciae trigger point model

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Eight 7-week-old male SD rats, weighing 270g-320g, were selected. Three days before the experiment, the rats ran adaptively on a flat slope for 15 minutes on the treadmill to familiarize them with and adapt to the experimental environment in advance. On the first day of every week, rats were subjected to percussion treatment. The supine position of rats under abdominal anesthesia was fixed on the self-made percussion model, and the percussion device with a weight of 1200 g was dropped freely from a height of 20 cm, and the marked part was vertically percussed. The contact area between the percussion device and the gastrocnemius muscle was about It was 1x1cm and the kinetic energy was 2.352J, hitting the upper part of the gastrocnemius muscle of the left hind limb once, causing blunt trauma to this part. On the second day, the treadmill eccentric exercise intervention was carried out. On the electric animal treadmill with an inclination angle of -16°, the rats were kept ...

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Abstract

The invention relates to a construction method of a rat muscular fasciae trigger point model. The method includes the following steps that 1, 7-week-old male SD rats are selected; 2, a rat muscular fasciae trigger point is prepared, wherein 3 days before an experiment, the rats are made to run on an adaptive flat slope on a treadmill for 15 minutes so that the rats can be familiar with and adapt to an experimental environment in advance, every week, on the first day, the rats are treated with beating, on the second day, treadmill centrifugal exercise intervention is conducted, the rats are normally fed in the remaining five days, the intervention is repeated for eight weeks, the rats enter the recovery phase, all the rats are free of any experimental intervention and normally fed for fourweeks, and the whole intervention period is twelve weeks; 3, after twelve weeks, the rats are weighed, the rat muscular fasciae trigger point formation situation is detected. Compared with the prior art, the muscular fasciae trigger point is established by the combination of beating and centrifugal movement, and a good-stability, high-replication and high-survival-rate research model is provided for the myofascial pain syndrome study.

Description

[technical field] [0001] The invention belongs to the field of biotechnology, in particular to a method for constructing a rat myofascial trigger point model. [Background technique] [0002] Over the past century, rats have been the preferred rodent experimental animals. Because many of the molecular and cellular structures of rats are similar to those of humans, they have been widely used in tumors, endocrine, digestion, urology, neurobiology, reproductive biology, immunology, etc. etc. have been extensively and in-depth researched. [0003] Myofascial pain syndrome is a common painful syndrome of skeletal muscle dysfunction, and it is also a common soft tissue disease in sports medicine. Establishing an animal model of myofascial trigger point is of great significance for the study of its pathogenesis and treatment. Rat, as a rodent, has been widely used in medical biology research. However, there are still few studies on rats applied to myofascial trigger points, and th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D1/00
CPCA61D1/00
Inventor 黄强民姚明华刘庆广刘琳李丽辉庞博
Owner SHANGHAI UNIV OF SPORT
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