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Microreaction chip, microfluidic mixing method and preparation method thereof

A micro-reaction and micro-fluid technology, applied in mixers, chemical instruments and methods, chemical/physical/physicochemical reactors, etc., can solve problems affecting production and limiting the effective length of micro-reaction channels, so as to increase production and prolong Micro-reaction channels, the effect of reducing occupancy

Active Publication Date: 2018-11-23
CHANGZHOU NAYANG BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] But this kind of micro-reaction channel system, owing to adopting the planarized micro-reaction channel design, needs larger micro-reaction channel layout area on the chip, has limited the effective length of micro-reaction channel; The design of the narrow outlet at the place increases the pressure drop of the fluid and affects the output

Method used

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  • Microreaction chip, microfluidic mixing method and preparation method thereof
  • Microreaction chip, microfluidic mixing method and preparation method thereof
  • Microreaction chip, microfluidic mixing method and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0066] figure 1 It is a structural schematic diagram of an embodiment of a micro-reaction chip of the present invention.

[0067] figure 2 It is a structural schematic diagram of the micro-reaction channel unit in the first embodiment of the present invention.

[0068] Such as figure 1 and figure 2 As shown, the present embodiment 1 provides a microreaction chip, including a microreaction channel unit 1; the microreaction channel unit 1 includes: two microchannels 100 stacked up and down, and the two microchannels 100 communicate with each other to The fluids in the two microchannels 100 are mixed with each other. After two different fluids are injected into the micro-reaction chip from the liquid inlet 6 , they are fully mixed by at least one micro-reaction channel unit 1 , and then discharged from the liquid outlet 7 . The micro-reaction channel unit 1 is the smallest unit of the micro-reaction chip, and the micro-reaction chip can complete a complete reaction channel...

Embodiment 2

[0100] see Figure 1 to Figure 10 , on the basis of Example 1, this Example 2 provides a microfluidic mixing method.

[0101] The two micro-channels 100 are stacked and communicated with each other, so that the fluids in the two micro-channels 100 cross and mix with each other during travel.

[0102] A set of convection holes 200 suitable for fluid back-and-forth crossing is communicated between the two micro-channels 100 , and a set of convection holes 200 includes two convection holes 200 , so that the fluids in the two micro-channels 100 are mixed back and forth.

[0103] In this embodiment, the specific structure and working principle of the micro-channel 100 have been described in detail in Embodiment 1 above, and will not be repeated here.

[0104] The beneficial effect of the present invention is that this mixing method, firstly, by stacking two micro-flow channels, the occupancy of the plane space is reduced, the three-dimensional space is rationally used, and the mic...

Embodiment 3

[0106] On the basis of Example 1, this Example 3 also provides a method for preparing a micro-reaction chip.

[0107] Specifically, the micro-reaction channel unit 1 adopts a multi-layer arrangement, and includes an intermediate layer and an upper and a lower layer, wherein on the contact surfaces of the upper, lower layer and the intermediate layer, there are respectively provided micro-reaction channel units along the micro-channel 100 in the micro-reaction channel unit. grooves; the middle layer corresponding to the micro-reaction channel unit 1 is provided with at least one set of convection holes 200; Through a set of convection holes 200, the two fluids pass back and forth between the two micro-channels to realize cross-mixing.

[0108] The preparation method of the micro-reaction chip has quick preparation and good preparation effect.

[0109] In summary, the micro-reaction chip uses the double-layered micro-channel 100 and the convection hole 200 to realize the upper ...

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Abstract

The invention provides a microreaction chip, a microfluidic mixing method and a preparation method thereof. The microreaction chip comprises a microreaction channel unit, wherein the microreaction channel unit comprises two micro channels which are stacked up and down; furthermore, the two micro channels are mutually communicated to enable fluid in the two micro channels to mutually mixed. According to the microreaction chip, firstly, the two micro channels are stacked, so that occupancy of plane space is reduced, and three-dimensional space is reasonably utilized; then, three-dimensional cross mixing of the fluid is achieved through communication between the stacked micro channels, so that the microreaction channels are lengthened, and the reaction efficiency is improved; furthermore, a narrowed outlet designed at the finished position of each microreaction channel unit is avoided; in addition, pressure drop of the fluid is reduced, the high flow speed of the fluid is ensured, the mixing efficiency is ensured, and the yield is simultaneously improved.

Description

technical field [0001] The invention relates to a chip, in particular to a micro-reaction chip, a microfluid mixing method and a preparation method thereof. Background technique [0002] Chinese patent: Micro-reaction channel system, application number: 201621259350.0, provides a micro-reaction channel system, including: a bottom plate and a micro-reaction channel, wherein the micro-reaction channel includes at least one material inlet and at least two symmetrical curved reaction walls And the two chambers defined by it, and at least one material outlet; the material inlet is between the first and second linear reaction walls opposite to each other, and the first curved reaction wall is connected to the first and third linear reaction walls respectively , the two chambers are connected and there is a curved barrier part in the middle. The cross-section of the two ends of the barrier part is S-shaped, and the cross-section of the middle part is linear. The two single steps of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J19/00B01F13/00B01L3/00
CPCB01J19/0093B01L3/502707B01J2219/00867B01F33/301
Inventor 沙俊
Owner CHANGZHOU NAYANG BIOTECHNOLOGY CO LTD
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