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Application of borneol as active ingredient of drug for relieving ultrasound targeted microbubble destruction induced focal cerebral ischemia blood-brain barrier opening

A technology of focal cerebral ischemia and targeted microbubbles, which is applied in the fields of active ingredients of hydroxyl compounds, drug combinations, and cardiovascular system diseases, and can solve problems such as brain tissue hemorrhage and aggravate the opening of the blood-brain barrier

Inactive Publication Date: 2018-11-27
SHANGHAI YANGPU CENT HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But while researchers are busy exploring how UTMD can effectively assist neuroprotective agents in treating central nervous system disorders, studies have also reported that UTMD's mechanical and cavitational effects can lead to normal brain tissue hemorrhage
At the same time, the inventors' preliminary experiments showed that a safe and relatively moderate parameter of UTMD to open the blood-brain barrier in normal mice exacerbates the opening of the blood-brain barrier in mice with ischemic stroke and causes cerebral microhemorrhage

Method used

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  • Application of borneol as active ingredient of drug for relieving ultrasound targeted microbubble destruction induced focal cerebral ischemia blood-brain barrier opening
  • Application of borneol as active ingredient of drug for relieving ultrasound targeted microbubble destruction induced focal cerebral ischemia blood-brain barrier opening
  • Application of borneol as active ingredient of drug for relieving ultrasound targeted microbubble destruction induced focal cerebral ischemia blood-brain barrier opening

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Embodiment Construction

[0015] Draw 0.5ml of Tween 80 (Tween80), dilute it in 9ml of sterile 0.01M PBS solution, and then dilute to 10ml to prepare 5% Tween solution. Take 9ml of the prepared 5% Tween solution, weigh 200mg borneol powder and dissolve it in 9ml of 5% Tween solution, then make the volume to 10ml, make a 20mg / ml mother solution, and store it in a refrigerator at 4°C.

[0016] The borneol used is dextroborneol, which was purchased from Renzheju Chinese Pharmacy in Haozhou City, and its structural formula is shown in the following formula:

[0017]

[0018] Pharmacological experiment

[0019] The following pharmacological experiments and results will further illustrate its drug activity. The experimental methods used in the following experiments are conventional experimental methods unless otherwise specified. The materials and reagents used in the following experiments can be obtained from commercial sources unless otherwise specified.

[0020] Prepare a sufficient amount of borneo...

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Abstract

The invention relates to a new application of a compound borneol in the field of pharmacy and discloses an application of borneol as an active ingredient of a drug for relieving ultrasound targeted microbubble destruction (UTMD) induced focal cerebral ischemia blood-brain barrier opening. The borneol is capable of relieving the further opening of the cerebral ischemia blood-brain barrier induced by UTMD, so that a safer strategy is supplied for UTMD adjuvant neuroprotective therapy after apoplexy.

Description

technical field [0001] The invention relates to a new application of the compound borneol in the field of pharmacy, in particular to the application of the borneol as an active ingredient in a medicine for alleviating the opening of the blood-brain barrier induced by ultrasound-targeted microbubble rupture technology. Background technique [0002] Stroke is the second most common cause of death and the leading cause of acquired disability worldwide. After decades of research on neuroprotective agents for ischemic stroke, no successful transformation has been achieved so far. This is because the blood-brain barrier is a highly selectively permeable barrier that effectively separates circulating blood from the central nervous system and plays a key role in maintaining the homeostasis of the brain. The blood-brain barrier opens during cerebral ischemia-reperfusion, which theoretically allows neuroprotective agents to enter the damaged brain tissue. However, targeted delivery ...

Claims

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Application Information

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IPC IPC(8): A61K31/045A61P9/10
CPCA61K31/045A61P9/10
Inventor 张晓光单畅岳蕴华朱晓琼刘凌云胡亮薛杰
Owner SHANGHAI YANGPU CENT HOSPITAL
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