Preparation method of methylene blue-containing silica/shellac composite particles for releasing methylene blue aggregate

Abstract

The invention provides a preparation method of methylene blue-containing silica / shellac composite particles for releasing methylene blue aggregate, and belongs to the technical field of chemical raw material production. The preparation method comprises the following steps: after adding ammonia water, methylene blue and ethyl orthosilicate to a mixed solution of water and ethanol, stirring for 4 hours, centrifuging, washing and drying at 70 DEG C, dispersing prepared methylene blue-containing silica particles in a shellac solution, then dropwise adding a phosphate buffer, after stirring for 1 hour, centrifuging, washing and drying at room temperature, and carrying out thermal treatment on prepared methylene blue-containing silica / shellac composite particles at 90-180 DEG C for 24 hours to obtain the methylene blue-containing silica / shellac composite particles for releasing methylene blue aggregate. The preparation method is simple in process, low in raw material price, and easy for industrial production, and the obtained particles have good biocompatibility and are easy for degradation. Methylene blue is released from interiors of the particles into the solution mainly in the form of dimers and trimers.

Description

Technical field [0001] A preparation method of methylene blue-containing silica / shellac composite particles releasing methylene blue aggregates belongs to the field of preparation methods of chemical raw materials. Background technique [0002] Photochemodynamic therapy is a new type of treatment that uses the active substances produced by the photochemical reaction of photosensitive molecules to destroy diseased cells to achieve the therapeutic effect. That is, the photosensitive molecules change from the ground state to the excited state under light excitation, and in the molecular excitation process, The excess energy is transferred to the surrounding oxygen molecules, turning the oxygen molecules into active singlet oxygen molecules to achieve a sterilization effect. This is the second type of photochemical reaction route; and under oxygen-free or low-oxygen conditions, photosensitive molecules pass through The charge transfer within the molecules of the photosensitive molecu...

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Problems solved by technology

[0005] Among them, methylene blue dimer can be obtained by increasing the concentration of methylene blue, and methylene blue can also be wrapped into a drug carrier to obtain a slow-release carrier of methylene blue dimer, such as the technical solution provided by ZL201410436007.8, but the technical solution The release behavior of the mentioned drug carrier has little difference in different solution environments, and the pH value sensitive effect of the dimer release behavior cannot be achieved, because the pH value in normal human tissues is 7.2~7.4, while the pH value in diseased cells is The value is about 4.3

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