Use of bulbus fritillariae total alkaloid extract in preparing medicines or health products for preventing and treating Hashimoto thyroiditis

A technology for Hashimoto's thyroiditis and total alkaloids is applied in the directions of drug combinations, medical preparations containing active ingredients, pharmaceutical formulations, etc., and can solve the use of Hashimoto's thyroiditis of fritillary and its total alkaloid extracts which have not been reported yet. and other problems, to achieve the effect of less toxic and side effects, good curative effect and good safety.

Inactive Publication Date: 2018-11-30
上海复活石医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there has been no report on the use of Fritillaria and its total alkaloid extracts in the prevention and treatment of Hashimoto's thyroiditis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Preparation of Fritillaria sichuan total alkaloid extracts with different contents

[0017] Chuan Fritillaria medicinal material is collected from Sichuan Province, China, and has been identified as a medicinal material under the item "Chuan Fritillaria" in "Chinese Pharmacopoeia" (2015 edition). Add 5kg of medicinal materials into 30L of 75% ethanol aqueous solution at a ratio of 1:6, use continuous reflux extraction method, extract with ethanol twice, each extraction time is 2 h, and filter. The combined filtrates were concentrated to dryness on a rotary evaporator under reduced pressure to obtain 450 g of the total alkaloid extract of Fritillaria de Chuanensis. Further purification with ion exchange column, according to the times of purification, the total alkaloid extracts C-1, C-2, C-3 and C-4 of Fritillaria sichuanensis were obtained with different contents. Then refer to the [Content Determination] method under the item of "Chinese Pharmacopoeia" (201...

Embodiment 2

[0018] Example 2: Preparation of different contents of total alkaloid extracts of I. japonicus

[0019] The medicinal material of I. fritillaria is collected from Xinjiang, China, and is extracted and purified by referring to the preparation method of the total alkaloid extract of Fritillaria chinensis in "Example 1", and the total alkaloids extracts Y-1, Y- 2. Y-3, Y-4, the alkaloid content of total alkaloid extracts Y-1, Y-2, Y-3, and Y-4 of Y. japonicus were 11.2%, 35.6%, and 53.2% respectively , 77.6%.

Embodiment 3

[0020] Embodiment 3: the preparation of the total alkaloid extracts of Fritillaria sichuanensis and Fritillaria japonicus with different contents

[0021] The medicinal materials of Fritillaria sichuanensis were collected from Sichuan Province, China, and the medicinal materials of Fritillaria sichuanensis were collected from Xinjiang, China. Half of the two were collected, and they were extracted and purified referring to the preparation method of the total alkaloid extract of Fritillaria sichuanensis in "Example 1", and different The mixed total alkaloid extracts H-1, H-2, H-3, H-4 of Chuan Fritillaria and I. Fritillaria. After determination, the total alkaloid extracts of I. Fritillaria H-1, H-2, The alkaloid contents of H-3 and H-4 were 10.7%, 32.6%, 54.5% and 78.8%, respectively.

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Abstract

The invention discloses a new application of bulbus fritillariae total alkaloid extract in preparing medicines or health products for preventing and treating Hashimoto thyroiditis. The bulbus fritillariae total alkaloid is bulbus fritillariae cirrhosae total alkaloid extract and / or sinkiang fritillary bulb total alkaloid extract. The new application proves that the bulbus fritillariae total alkaloid has a good pharmacological function in treating the Hashimoto thyroiditis, the bulbus fritillariae total alkaloid can be used for preparing the medicines or health products for treating the Hashimoto thyroiditis, and a good clinical application prospect is achieved.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to the use of traditional Chinese medicine extracts, in particular to the application of fritillaria total alkaloid extracts in the preparation of medicines or health care products for preventing and treating Hashimoto's thyroiditis. Background technique [0002] Hashimoto's thyroiditis (HT), also known as chronic lymphocytic thyroiditis (CLT), autoimmune thyroiditis and Hashimoto's thyroiditis. Hashimoto's thyroiditis is a chronic autoimmune disease with autoimmune thyroid tissue as antigen and Thyroglobulin Antibody (TgAb) and Thyroid Peroxidase Antibody (TPOAb) as antibodies. Hypothyroidism is the most common cause of Hashimoto’s thyroiditis. It is an immune disease characterized by a large number of lymphocytes infiltrating the thyroid tissue and destruction of follicular cells. Serological tests show thyroid peroxidase antibody (TPOAb), Significantly elevated conce...

Claims

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Application Information

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IPC IPC(8): A61K36/8966A61P5/14A61P37/02A61K125/00
CPCA61K36/8966A61P5/14A61P37/02
Inventor 杨茗橘程芬
Owner 上海复活石医药科技有限公司
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