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Application of cinobufagin

A technology of cinobufacin and pulmonary fibrosis, applied in medical preparations containing active ingredients, respiratory diseases, organic active ingredients, etc., can solve the problems of cinobufacin-free pulmonary fibrosis and other problems, and achieve the level of inhibition of pulmonary fibrosis , inhibit excessive deposition, easy to accept the effect

Inactive Publication Date: 2018-12-07
TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Up to now, there is no related report that cinobufacin can slow down pulmonary fibrosis

Method used

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  • Application of cinobufagin
  • Application of cinobufagin
  • Application of cinobufagin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Establishment of mouse pulmonary fibrosis model and pharmacodynamic testing

[0036] Experimental method and steps:

[0037] 1. Establishment of mouse pulmonary fibrosis model

[0038] The 36 mice were randomly divided into three groups, blank control group (normal saline group), pulmonary fibrosis model group (bleomycin), cinobufacin group (administered cinobufacin after modeling), 12 only.

[0039] Pulmonary fibrosis animal model preparation refers to male C57BL / 6J, (age 8-10 weeks) wild-type mice, with 10% chloral hydrate by intraperitoneal injection of 0.5ml / 100g to give mice anesthesia, intratracheal invasive injection of 2U / Kg bleomycin. The specific implementation method is as follows: after the mouse is anesthetized, weigh and record, fix the mouse on the operating table, disinfect the neck with 70% alcohol, use a scalpel to make a vertical wound of about 1 cm in the neck of the mouse, and use micro tweezers to separate The tissue exposed the trac...

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PUM

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Abstract

The invention provides novel application of cinobufagin in preparation of medicine for treating pulmonary fibrosis. According to the application, the cinobufagin has an excellent effect on pulmonary fibrosis without adverse response, can be used for retarding pulmonary fibrosis of a mouse induced by bleomycin, and provides an excellent application prospect for treating, relieving or improving pulmonary fibrosis diseases.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to the application of cinobufacin. Background technique [0002] Pulmonary fibrosis (PF) is the common outcome of many pulmonary interstitial diseases with different etiologies. It is characterized by deposition, maintained and promoted by abnormal epithelial-interstitial interactions, resulting in varying degrees of inflammation and fibrosis in the alveoli and pulmonary interstitium, leading to structural destruction of the lungs and respiratory failure, so it is also called interstitial lung Disease (interstitial lung disease, ILD) or diffuse parenchymal lung disease (diffuse parenchymal lung disease, DPLD). [0003] Idiopathic pulmonary fibrosis (IPF) belongs to the idiopathic interstitial pneumonia (IIP) group in the family of interstitial lung diseases (ILDs). IPF is the most common and severe chronic inflammatory interstitial lung disease with unknown etiology. It is clini...

Claims

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Application Information

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IPC IPC(8): A61K31/585A61P11/00
CPCA61K31/585A61P11/00
Inventor 饶子和周红刚杨诚孙涛李霄鹤漆敏高晶晶刘帅帅黄梦莹毛家贺黄凯吕紫薇
Owner TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE
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