Application of panax notoginseng saponins in preparing NLRP3 inflammasome-restraining drugs or drugs for treating tristimania

A technology of Panax notoginseng saponins and inflammasomes, which can be used in drug combinations, antipyretics, anti-inflammatory agents and other directions to achieve the effect of improving depressive behavior
CN108938697AInactive Publication Date: 2018-12-07NANHUA UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NANHUA UNIV
Publication Date
2018-12-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the technical field of new applications of drugs and especially relates to an application of panax notoginseng saponins in preparing NLRP3 inflammasome-restraining drugs or drugs for treating tristimania. A test result proves that panax notoginseng saponins is capable of obviously restraining activation of LPS-induced rat hippocampal microglia and release of NLRP3 inflammasome and IL-1 beta and IL-18 and can be used for treating tristimania induced by abnormal increasing of microglia NLRP3 inflammasome.
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Description

technical field

[0001] The invention relates to the technical field of new application of drugs, in particular to the application of Panax notoginseng saponins in the preparation of drugs for inhibiting NLRP3 inflammasomes or drugs for treating depression. Background technique

[0002] The NLRP3 inflammasome has the function of regulating the chronic inflammatory response of the body, and its composition includes NLRP3 (NLRfamily, pyrin domain containing 3), apoptosis-associated speck-like protein containing CARD (ASC) and cysteine ​​day Cysteine-requiring aspartate protease-1 (Caspase-1), a cytoplasmic sensor of endogenous or exogenous danger signals, is a molecular platform for activating caspase-1, and regulates interleukin- Maturation and secretion of pro-inflammatory cytokines such as 1β (Interleukin-1β, IL-1β) and IL-18.

[0003] NLRP3 is one of the danger signal receptors in innate immune cells, which can be activated by various pathogen-associated molecular patterns...

Claims

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