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Method for predicting effect of drug

A prediction method and drug technology, applied in the fields of biochemical equipment and methods, drug screening, pharmaceutical formulations, etc., can solve the problems of ambiguous standards, lack of test guidelines, therapy test comparison, long test report time, etc.

Active Publication Date: 2018-12-11
山西加乐医疗科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Various chemosensitivity and resistance assays have been developed, but due to low success rates, ambiguous criteria for defining in vitro sensitivity, long turnaround time, and lack of test-guided therapy (assay-guided therapy) compared with empirical therapy (empirical therapy), and thus rarely proven to be useful in clinical practice

Method used

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  • Method for predicting effect of drug
  • Method for predicting effect of drug
  • Method for predicting effect of drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0041] The following embodiments are not intended to limit purposes, but are only used to present various aspects and characteristics of the invention.

[0042] Preparation of cellulose sponge

[0043] Preparation of cellulose sponge can be carried out in the following two steps:

[0044] 1. Synthesis of hydroxypropyl cellulose containing a substituent: (1) adding hydroxypropyl cellulose (molecular weight ≈ 10,000) to toluene to dehydrate by azeotropic distillation; (2) Dissolve 3.0 g of dehydrated hydroxypropyl cellulose in 120 ml of dimethylformamide (DMF); (3) dissolve 3.84 ml of allyl isocyanate (allyl isocyanate) in In 5 milliliters of DMF, this solution is slowly added dropwise in the hydroxypropyl cellulose solution of above-mentioned (2); The volume of alcohols is 30% of the total volume of the DMF solution (125 ml of DMF × 30% = 37.5 ml, the volume ratio of DMF: alcohols is 3.3: 1); (5) add a drop of dibutyltin dilaurate (dibutyltin dilaurate) as a catalyst; (6) st...

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Abstract

A method for predicting an effect of a medication or a treatment regimen to a subject suffering from a cancer, the method comprises: (A) obtaining a tissue from the subject and dissociating the tissueto obtain a multicellular cluster, wherein the multicellular cluster comprises the cancer cell; (B) culturing the multicellular cluster on a cellulose sponge; (C) exposing the cultured multicellularcluster to the medication or the treatment regimen; and (D) measuring a first survival rate of the cancer cell before exposing to the medication or the treatment regimen and a second survival rate ofthe cancer cell after exposing to the medication or the treatment regimen, when the second survival rate is lower than the first survival rate, the method predicts positive effect of the medication orthe treatment regimen to the subject.

Description

technical field [0001] The invention relates to a method for predicting the curative effect of medicine. Background technique [0002] Individual variability in response to drugs complicates the treatment of many diseases. Even within a highly homogeneous group (such as the same sex or similar age), some individuals respond well to a particular drug while others respond well. React poorly to that particular drug. [0003] Predicting the effect of chemotherapy before administering chemotherapy to a patient can help improve the patient's chemotherapy response, reduce toxicity and cost of care, thereby providing a tailored treatment plan for the patient. Chemosensitivity assays refer to any in vitro assay performed in a laboratory specifically to analyze the efficacy of a known chemotherapeutic drug in inhibiting tumor growth. An ideal in vitro chemosensitivity test should be reproducible, use a small amount of tissue, and be rapid and accurate in predicting clinical response...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/02C12N5/09A61K33/243
CPCC12N5/0693G01N33/5011C12N2513/00A61K33/243G01N2800/52C12N5/0062C12N5/0093G01N33/5082A61K31/505C12N2503/02C12N2533/78C12N5/0677G01N33/5091
Inventor 谢志强张岩
Owner 山西加乐医疗科技有限责任公司
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