Compound externally-used bifonazole composition

A technology of compound bifonazole and topical composition, which is applied in the field of topical antifungal composition to achieve good antibacterial effect and improve the effect of treatment

Inactive Publication Date: 2018-12-14
泮宝峰 +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the widespread use, the resistance of fungal pathogens to bifonazole has become more and more prominent, and the existing 1% bifonazole topical preparations have become more and more incapable of dealing with skin mycosis

Method used

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  • Compound externally-used bifonazole composition
  • Compound externally-used bifonazole composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Pharmacological Example 1, Preparation of drug-resistant strains

[0012] Preparation

[0013] 1) The standard strain adopts Trichophytonrubrum (No.: ATCC228188), inoculate the standard strain of Trichophyton rubrum on the potato dextrose agar (PDA) medium, and activate it in an incubator at 28°C for 7-14d , select a colony with good growth status and no pollution as the test strain, and select a colony with good growth status and no pollution

[0014] As the test strain, an appropriate amount of 0.85% sterile saline was added dropwise to the colony, and the surface of the colony was gently and repeatedly scraped with a sterile cotton swab to fully mix the spores with the saline. Use two layers of gauze to filter the bacterial suspension into a centrifuge tube, and place it in a vortex shaker for about 15 seconds. Count with a hemocytometer, and adjust the concentration of the bacterial solution to 2-6×10 with sterile saline. 5 cfu / mL, and finally diluted 10 times wi...

Embodiment 2

[0017] Pharmacological embodiment 2, in vitro antibacterial effect experiment

[0018] 1. Preparation of culture medium

[0019] Potato dextrose agar medium (PDA), the mass fraction is potato 20%, glucose 2%, agar 1.8%. Add 5ml of medium to each test tube to prepare a slant medium; add 20ml of medium to a plate with a diameter of 90mm to prepare a plate medium

[0020] 2. Experimental method

[0021] 2.1 Treatment of strains

[0022] 1. The artificially induced drug-resistant Trichophyton rubrum bacterial strain and the standard bacterial strain prepared in Pharmacological Example 1 were respectively replanted on a flat plate PDA medium to activate the bacterial strain using a sterile inoculation loop. Incubate for 7 days in a constant temperature incubator at 28°C.

[0023] 2.2 Making bacterial suspension

[0024] Pick an appropriate colony mass and dissolve it in 1 mL of 0.9% sterilized saline with Tween 80 added. Vibrate with a micro-oscillator for 2 minutes, fully os...

Embodiment 3

[0047] Butterbur lactone H 4.8g, bifonazole 12g

[0048] Carbomer 940 15g Glycerol 50g Tween 80 5g

[0049] Add ethyl paraben 1g sodium hydroxide 4g distilled water to 1000g

[0050]Mix carbomer with Tween 80 and 300ml distilled water, adjust the pH of the supernatant to 7 with 0.1M sodium hydroxide solution, then dissolve bifonazole and butterbur lactone H in ethanol and gradually add and stir well to make up the remaining Amount of water is stirred evenly to obtain a transparent gel.

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PUM

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Abstract

A compound externally-used bifonazole composition comprises bifonazole and butterbur lactone H as active components, and at least one auxiliary material suitable for external use on skin; in the externally-used composition, the mass ratio of the butterbur lactone H to the bifonazole is 1:(1.5-2.5). The composition is prepared into a gel, an auxiliary material of the gel is one or more of carbomer,a wetting agent, a solvent, a preservative, a surfactant and a pH adjuster, and water is used as the balance.

Description

Technical field: [0001] The invention provides an antifungal composition for external use. Background technique: [0002] Bifonazole (CAS: 60628-96-8), as a broad-spectrum antifungal drug, is widely used in the treatment of fungal skin diseases. Fungal skin diseases refer to human skin, mucous membranes, and hair caused by pathogenic fungi. A large class of infectious diseases of skin appendages such as A and A have a variety of pathogenic bacteria, such as Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum gypsum and Candida (Candida glabrata, Candida albicans) and the like. Due to the widespread use, the resistance of fungal pathogens to bifonazole has become more and more prominent, and the existing 1% bifonazole topical preparations have become more and more incapable of dealing with skin mycosis. Continuing to increase the dose will cause the potential risk of side effects to increase, and it is easier to stimulate the resistance of pathogenic bacteria, so h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4174A61K31/343A61K31/22A61K9/06A61P31/10
CPCA61K9/0014A61K9/06A61K31/22A61K31/343A61K31/4174A61K47/32A61P31/10A61K2300/00
Inventor 董芳梅童小丽王文坤赵振燕
Owner 泮宝峰
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