Up-regulation long-chain non-coding RNA markers for lung cancer and application thereof

A marker, non-coding technology, applied in the field of biomedicine, can solve the problems of lung injury, risk, sensitivity and specificity need to be improved, etc., and achieve the effect of high accuracy and high sensitivity
CN108998530AActive Publication Date: 2018-12-14FIRST AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FIRST AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIV
Publication Date
2018-12-14

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Abstract

The invention discloses up-regulation long-chain non-coding RNA markers for lung cancer and an application thereof. The markers are combinations of AC089998.4, AC103925.1, AC113189.2, AC130324.2, AC239868.1, AL031985.3, AL079303.1, AL121902.1, AP000873.3, PCAT6 and PVT1. The markers can be used alone or in combination of two kinds or in combination of more than two kinds for early diagnosis of lung cancer. 11 lung cancer markers provided by the invention have the characteristics of high accuracy and high sensitivity. All the areas AUC of the 11 markers under a prediction line are larger than 0.9, and the 11 markers are suggested to have the characteristics of high accuracy and high sensitivity.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine, and in particular relates to a lung cancer up-regulated long-chain non-coding RNA marker and its application. Background technique

[0002] Lung cancer is the malignant tumor with the highest incidence rate in China and the world, and it is also the leading cause of cancer death in men. The incidence of lung cancer in the female population is second only to breast cancer. Global Burden of Disease (GBD) data shows that in 2016, the number of people suffering from trachea, bronchus or lung cancer in the world exceeded 2.8 million, of which the number of patients in China was as high as 1 million. In 2016, the number of deaths from the above-mentioned cancers worldwide was 1.7 million, accounting for 3.12% of the total deaths. In 2016, the number of patients who died in China was 590,000, accounting for 6.11% of the total number of deaths. Statistics show that from 1990 to 2016, the global pr...

Claims

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