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Double-modified collagen scaffold and its application in products for repairing spinal cord injury

A collagen scaffold and double modification technology, applied in the field of biomedical materials, can solve the problems of neuron regeneration and functional recovery are not optimistic

Active Publication Date: 2021-05-07
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, there are more and more repair strategies to guide nerve regeneration after spinal cord injury, but research on spinal cord injury repair targeting a single factor can only promote nerve regeneration after injury to a certain extent
The neuron regeneration and functional recovery that can be observed in the repair method only targeting a specific factor are not optimistic

Method used

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  • Double-modified collagen scaffold and its application in products for repairing spinal cord injury
  • Double-modified collagen scaffold and its application in products for repairing spinal cord injury
  • Double-modified collagen scaffold and its application in products for repairing spinal cord injury

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preparation example Construction

[0053] The embodiment of the present invention also provides the preparation method of the aforementioned double modified collagen scaffold, which comprises:

[0054] The EGFR antibody and the microtubule stabilizing molecule are simultaneously dissolved in a selected solvent, then dropped onto the collagen scaffold material, and incubated overnight at 4-20° C. to obtain a double-modified collagen scaffold.

[0055] Further, the preparation method further includes: pretreating the collagen scaffold material with a physical and chemical decellularization method.

[0056] Further, the solvent includes phosphate buffer saline (PBS).

[0057] The embodiment of the present invention also provides a functional product for repairing spinal cord injury, which comprises the aforementioned double-modified collagen scaffold.

[0058] In summary, in order to supplement the lost neurons at the site of spinal cord injury, promote the regeneration of nerve fibers, and eliminate the inhibito...

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Abstract

The invention discloses a double-modified collagen scaffold and its application in products for repairing spinal cord injuries. The double modified collagen scaffold includes collagen scaffold material, and EGFR antibody and microtubule stabilizing molecule modified on the collagen scaffold material. In the present invention, the EGFR antibody cetuximab and the microtubule stabilizing molecule paclitaxel are used to modify the linear ordered collagen scaffold material, which can not only effectively antagonize the inhibitory effect of myelin sheath-related inhibitory molecules on nerve regeneration by blocking the activation of the EGFR signaling pathway, but also promote spinal cord injury. More neurons are produced in the site, which is conducive to the myelination of nerve fibers. It can also promote the regeneration of axons and reduce the deposition of inhibitory scar components in the injured area by stabilizing the structure of microtubules, hindering the formation of inhibitory scars, thereby rebuilding the spinal cord. neural circuits, ultimately enabling better recovery of behavioral function after spinal cord injury.

Description

technical field [0001] The invention relates to a double-modified collagen scaffold, in particular to a linear ordered collagen scaffold for repairing spinal cord injuries and a preparation method thereof, as well as its application in preparing products for repairing spinal cord injuries, belonging to the technical field of biomedical materials . Background technique [0002] Spinal cord injury is a common severe central nervous system injury clinically, often causing permanent sensory and motor dysfunction below the level of injury, which brings great pain to patients and their families. Moreover, the current treatment of spinal cord injury still faces major challenges. [0003] Collagen is the main component of the extracellular matrix, which has the characteristics of good biocompatibility and low immunogenicity. Collagen materials can be used as biomaterials for guiding nerve regeneration. Previously, the inventor of this case developed a linear and ordered collagen ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/24A61L27/22A61L27/00A61L27/54A61L27/50
CPCA61L27/00A61L27/227A61L27/24A61L27/50A61L27/54A61L2300/256A61L2300/416A61L2430/32C08L89/00
Inventor 戴建武李晓然范彩霞
Owner SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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