Blood viscoelasticity measurement device and method based on piezoresistive micro suspension bridge sensor

Abstract

The invention provides a blood viscoelasticity measurement device and a method based on a piezoresistive micro suspension bridge sensor. The device comprises a microfluid device, permanent magnets anda signal excitation detection circuit, wherein the microfluid device comprises substrates; a microchannel is carved on the upper surface of one substrate; the microchannel is provided with two inputends and an output end; the piezoresistive micro suspension bridge sensor is mounted in the microchannel; a liquid flows in and meets through the two input ends, flows through the piezoresistive microsuspension bridge sensor and flows out from the output end; the permanent magnets are placed on the two sides of the microfluid device and used for providing a constant magnetic field to the piezoresistive micro suspension bridge sensor; the signal excitation detection circuit is connected with the piezoresistive micro suspension bridge sensor and used for measuring viscoelasticity change in a blood coagulation process. The device can quickly and accurately measure the viscoelasticity of a blood sample under the condition of a smaller amount of blood and meets requirements of clinical blood coagulation detection and analysis at present.

Description

technical field [0001] The invention relates to a measurement technology for rapidly detecting blood viscoelasticity, in particular to a viscoelasticity measurement device and method for trace blood samples based on a piezoresistive micro-suspension bridge sensor. Background technique [0002] Blood coagulation is the process in which flowing blood becomes coagulated, and its essence is the process in which soluble fibrinogen in plasma becomes insoluble fibrin. The detection of blood coagulation function is extremely important for predicting the risk of postoperative blood loss, judging the cause of bleeding, and guiding the implementation of hemostasis measures, especially for operations with a large amount of bleeding such as cardiovascular surgery, obstetric surgery, and orthopedic surgery. [0003] At present, commonly used methods for blood coagulation detection include platelet count, fibrinogen concentration, thromboelastography (TEG), rotational thromboelastometry (R...

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Problems solved by technology

Thromboelastography instrument needs to put the cup head into the cup body and it is not easy to keep it upright, which makes it difficult to align the probe when inserted into the cup head, which is not conducive to the operation of the cup

The above method has low sensitivity and requires too much blood for each test. Therefore, it is difficult to meet the needs of current clinical coagulation detection and analysis.

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