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A kind of lung cancer marker anti-hmgb3 autoantibody and its application

One-HMGB3, autoantibody technology, applied in the field of lung cancer marker anti-HMGB3 autoantibody, can solve the problem of unsatisfactory tumor markers

Active Publication Date: 2021-04-23
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the problem of unsatisfactory existing tumor markers of lung cancer, aiming at improving the sensitivity, specificity and accuracy of early diagnosis of lung cancer

Method used

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  • A kind of lung cancer marker anti-hmgb3 autoantibody and its application
  • A kind of lung cancer marker anti-hmgb3 autoantibody and its application
  • A kind of lung cancer marker anti-hmgb3 autoantibody and its application

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Experimental program
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Effect test

Embodiment 1

[0029] 1. Serum Specimen Collection

[0030] In the test stage of the present invention, 184 lung cancer patients and 184 normal human sera were used in total to conduct preliminary evaluation of anti-HMGB3 autoantibodies in the diagnosis of lung cancer; in the verification stage, 446 lung cancer patients, 446 normal people and 119 benign lung diseases were used. Patient sera were subjected to further evaluation of anti-HMGB3 autoantibodies in the detection of lung cancer. All lung cancer patients were pathologically diagnosed as lung cancer, normal subjects came from routine physical examination population, and all non-cancer subjects were confirmed to be free from tumor-related diseases and autoimmune diseases. The blood samples were centrifuged at 3500 rpm for 5 minutes, the serum was aliquoted and labeled, and stored in a -80°C refrigerator for later use.

[0031] . Screening of Oncomine database

[0032] The invention excavates and screens the relevant information of l...

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Abstract

The invention belongs to the technical field of biomedical detection, and in particular relates to a lung cancer marker anti-HMGB3 autoantibody and its application. The invention discloses a lung cancer marker, and the lung cancer marker is an anti-HMGB3 autoantibody. The present invention also provides the application of the above-mentioned lung cancer markers in the preparation of a lung cancer detection kit. The present invention aims to provide a clinically applicable lung cancer marker with simple operation, low cost, high accuracy and non-invasiveness and a reagent kit for preparing the marker for lung cancer evaluation. The research of the present invention found that the application of ELISA method to detect serum anti-HMGB3 autoantibodies can more accurately distinguish lung cancer patients from normal people, as well as patients with benign lung disease groups (COPD and chronic bronchitis), and can be used for lung cancer early detection. In this context, the convenient, fast and effective marker anti-HMGB3 autoantibody for detecting lung cancer patients and the kit for preparing the marker for lung cancer detection are provided, which can be used for clinical early diagnosis of lung cancer.

Description

technical field [0001] The invention belongs to the technical field of biomedical detection, and in particular relates to a lung cancer marker anti-HMGB3 autoantibody and application thereof. Background technique [0002] Lung cancer is one of the malignant tumors with the highest morbidity and mortality worldwide. According to the national malignant tumor registration data collected by the National Cancer Registration Center in 2017, the incidence and mortality of lung cancer in my country rank first among malignant tumors, and the incidence and mortality have increased year after year. The high incidence of lung cancer is closely related to the prognosis of lung cancer patients and its course of disease. With the development of the course of the disease, the survival rate of patients decreases significantly. Taking non-small cell lung cancer as an example, the 5-year survival rate of stage I patients treated with surgery is 70–90%, while most patients with stage IV can on...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/574
CPCG01N33/57484
Inventor 欧阳松云赵春玲苏皎刘峰辉王梦歌马小花代丽萍
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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