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Methods and apparatus for physicochemical characterization of materials

A technology of physical and chemical properties and characterization, applied in the field of physical and chemical characterization of substances, it can solve the problems of changing particle properties and mechanical adhesion, and achieve the effect of reducing contact and consumption.

Active Publication Date: 2022-02-22
エルエスキャンサーディアグオーワイ
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Mechanical attachment is laborious and potentially alters particle properties
On the other hand, localization is often challenging and temporary, especially for small particles

Method used

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  • Methods and apparatus for physicochemical characterization of materials
  • Methods and apparatus for physicochemical characterization of materials
  • Methods and apparatus for physicochemical characterization of materials

Examples

Experimental program
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Embodiment Construction

[0047] definition

[0048]logP / logD refers to the partition / distribution coefficient. It characterizes the lipophilicity of compounds, determining their distribution eg in the environment and in the human body.

[0049] The pH-independent partition coefficient P or the pH-dependent distribution coefficient D describes eg permeation and absorption phenomena in biofilms.

[0050] figure 1 A schematic flow diagram of the method is shown. First, at least one particle (1) is provided on the surface. A fluid (2) is provided and the fluid is contacted (3) with the particle(s). The particle(s) are imaged (4) when the particle(s) are in contact with the fluid. The images acquired during the detection are analyzed (5). Following image analysis, at least one physicochemical property of the particle(s) is determined (6) using information obtained from the analyzed images.

[0051] When a particle(s) interacts with a fluid, for example when a solvent acting as a fluid dissolves t...

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PUM

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Abstract

A characterization method comprising the steps of: (i) providing a particle on a surface, (ii) providing a fluid, (iii) allowing the fluid to contact the particle, (iv) detecting the particle, (v) based on the data obtained in step (iv) analyzing the changes in the particles; and (vi) correlating the changes in the particles with the material of the particles or the physicochemical properties of the fluid.

Description

technical field [0001] The present invention generally relates to the physicochemical characterization of substances. Background technique [0002] Based on automated image analysis, high-content analysis (HCA) has become a widely used and valuable technique in biological sciences. [0003] In particular, two physicochemical properties of materials, namely solubility and lipophilicity, determine their fate in different chemical environments. The solubility of a compound determines the extent to which the compound exists in its molecularly active form, eg, thus determines the bioavailability, and the extent to which the compound will exhibit a therapeutic or toxic effect. For example, solubility also plays an important role during nucleation, which is highly relevant in synthesis and crystallization. [0004] The partition / distribution coefficient (logP / logD) describes the lipophilicity of a compound, which determines the partition eg in the environment and in the human bod...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N13/00
CPCG01N13/00G01N2013/006G01N33/15G01N1/4055G01N15/1433G01N33/4833G01N2015/1006G01N2015/1495G01N2015/1497
Inventor S·斯万巴克J·于利鲁西H·埃勒斯O·安蒂凯南H·莱克南
Owner エルエスキャンサーディアグオーワイ
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