Compound with antitumor effect and its preparation method and application

A technology of anti-tumor effects and compounds, applied in the direction of anti-tumor drugs, rhodium organic compounds, chemical instruments and methods, etc., can solve the problems of reducing the anti-tumor effects of nucleoside drugs, mutation of tumor cell lines, strong toxic side effects, etc., to achieve Good biological activity and efficacy, less toxic and side effects, and stable molecular structure

Active Publication Date: 2020-08-14
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the anti-tumor drugs used clinically are nucleoside drugs, which have strong toxic and side effects due to the similarity in anti-tumor spectrum of nucleoside drugs
On the other hand, some tumor cell lines are prone to drug resistance to clinically used drugs, which will cause tumor cell lines to mutate easily and reduce the anti-tumor effect of nucleoside drugs
[0003] Dozens of anti-tumor drugs currently used in clinical chemotherapy or adjuvant medicine have a good curative effect on the treatment of some tumors

Method used

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  • Compound with antitumor effect and its preparation method and application
  • Compound with antitumor effect and its preparation method and application
  • Compound with antitumor effect and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A compound with anti-tumor effect, the structural formula of the compound is:

[0033]

[0034] A preparation method of a compound with anti-tumor effect, comprising the following steps:

[0035] S1. Dissolve 9-anthracene formaldehyde and 4-phenyl-3-thiosemicarbazide in absolute ethanol, then add glacial acetic acid, heat to reflux, cool and filter to obtain 9-anthracene-N 4 - phenylthiosemicarbazide;

[0036] S2, the 9-anthracene-N 4 - Phenylthiosemicarbazide and dichloro(pentamethylcyclopentadienyl) rhodium (III) dimer are dissolved in ethanol and mixed, and the solvent is removed by rotary evaporation to obtain a red solid, which is the compound of the anti-tumor effect .

[0037] In the preparation method of the compound with anti-tumor effect, the heating and reflux time in S1 is 3 hours.

[0038] In the preparation method of the compound with anti-tumor effect, the mixing temperature in S2 is 15° C. and the mixing time is 3 hours.

[0039] In the preparati...

Embodiment 2

[0043] A preparation method of a compound with anti-tumor effect, comprising the following steps:

[0044] S1. Dissolve 9-anthracene formaldehyde and 4-phenyl-3-thiosemicarbazide in absolute ethanol, then add glacial acetic acid, heat to reflux, cool and filter to obtain 9-anthracene-N 4 - phenylthiosemicarbazide;

[0045] S2, the 9-anthracene-N 4 - Phenylthiosemicarbazide and dichloro(pentamethylcyclopentadienyl) rhodium (III) dimer are dissolved in ethanol and mixed, and the solvent is removed by rotary evaporation to obtain a red solid, which is the compound of the anti-tumor effect .

[0046] In the preparation method of the compound with anti-tumor effect, the heating and reflux time in S1 is 4 hours.

[0047] In the preparation method of the compound with anti-tumor effect, the mixing temperature in S2 is 25° C. and the mixing time is 4 hours.

[0048] In the preparation method of the anti-tumor compound, S2 also includes recrystallizing the obtained red solid in dic...

Embodiment 3

[0052] A preparation method of a compound with anti-tumor effect, comprising the following steps:

[0053] S1. Dissolve 9-anthracene formaldehyde and 4-phenyl-3-thiosemicarbazide in absolute ethanol, then add glacial acetic acid, heat to reflux, cool and filter to obtain 9-anthracene-N 4 - phenylthiosemicarbazide;

[0054] S2, the 9-anthracene-N 4 - Phenylthiosemicarbazide and dichloro(pentamethylcyclopentadienyl) rhodium (III) dimer are dissolved in ethanol and mixed, and the solvent is removed by rotary evaporation to obtain a red solid, which is the compound of the anti-tumor effect .

[0055] In the preparation method of the compound with anti-tumor effect, the heating and reflux time in S1 is 5 hours.

[0056] In the preparation method of the compound with anti-tumor effect, the mixing temperature in S2 is 30° C. and the mixing time is 6 hours.

[0057] In the preparation method of the anti-tumor compound, S2 also includes recrystallizing the obtained red solid in dic...

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Abstract

The invention discloses a compound with an anti-tumor effect. The chemical name of the compound is monochloride-chlorine-(9-anthracene-N<4>-phenyl thiosemicarbazide)-pentamethyl cyclopentadienyl rhodium (III); the structure formula of the compound is shown in description. The compound has a very good inhibition effect on human prostate cancer PC3 cells and human ovarian cancer SKOV3 cells, and canbe used for preparing medicine for treating prostate cancer and ovarian cancer.

Description

technical field [0001] The invention relates to the field of synthetic compounds, in particular to a compound with antitumor effect. Background technique [0002] Cancer is one of the most important diseases that endanger human health, and there is still no effective treatment. Most of the antineoplastic drugs currently used clinically are nucleoside drugs, which have strong toxic and side effects due to the similarity in antitumor spectrum of nucleoside drugs. On the other hand, some tumor cell lines are prone to drug resistance to clinically used drugs, which leads to mutations in tumor cell lines and reduces the anti-tumor effect of nucleoside drugs. [0003] Dozens of anti-tumor drugs currently used in clinical chemotherapy or adjuvant medicine have good curative effect on some tumors. In this sense, the development of anti-tumor drugs that can overcome the drug resistance of tumor cell lines or have broad-spectrum activity, especially new anti-tumor complexes with syn...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F15/00A61P35/00A61P9/12A61K31/28
CPCA61P9/12A61P35/00C07F15/0073
Inventor 李培源苏炜霍丽妮陈睿
Owner GUANGXI UNIV OF CHINESE MEDICINE
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