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Regulatory network construction and analysis method based on breast cancer diseases

A technology of gene regulation network and analysis method, which is applied in the field of gene regulation network construction and analysis based on breast cancer disease, can solve problems such as inability to describe gene regulation relationship, inability to effectively meet genome-scale regulation network modeling, etc., and achieve the goal of promoting research. Effect

Active Publication Date: 2019-01-18
NORTHEASTERN UNIV LIAONING
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Problems solved by technology

Mutual information can support large-scale network modeling, but cannot describe the regulatory relationship between genes
Multi-model combination can improve the above two problems, but it still cannot effectively meet the needs of genome-scale regulatory network modeling

Method used

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  • Regulatory network construction and analysis method based on breast cancer diseases
  • Regulatory network construction and analysis method based on breast cancer diseases
  • Regulatory network construction and analysis method based on breast cancer diseases

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Embodiment Construction

[0048] The invention will be further described below in conjunction with the accompanying drawings and specific implementation examples: a method for constructing and analyzing a gene regulation network based on breast cancer disease, and its process is as follows figure 1 As shown, it includes the preliminary screening process of breast cancer-related genes, the process of gene regulatory network modeling and the process of gene regulatory network analysis, specifically including:

[0049] Step 1: Preliminary screening of breast cancer-related genes: divide breast cancer genes into benchmark genes, related genes and screened related genes. Benchmark genes refer to genes that have been identified as related to breast cancer in the prior art, a total of 40 genes , related genes refer to all genes except the prior art. In this embodiment, 24236 genes are selected, and the related genes screened out refer to the genes closely related to breast cancer disease screened by the method...

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Abstract

The invention provides a gene regulatory network construction and analysis method based on breast cancer diseases. The flow comprises the steps: preliminary screening of breast cancer-related genes; construction of the gene regulatory network; performing node centrality analysis according to the result of the gene regulatory network, including node degree centrality, approximation centrality, intermediary centrality and eigenvector centrality; and taking the first N data of network node degree centrality, approximation centrality, intermediary centrality and eigenvector centrality as the selected related genes. The breast cancer-related genes are effectively selected out from human genes so as to establish the gene regulatory network related to the breast cancer diseases, important genes are obtained through node centrality analysis, the research on the breast cancer diseases from the perspective of genetics can be promoted and a foundation can be laid for finding an effective way to intervene the breast cancer diseases.

Description

technical field [0001] The invention belongs to the field of medical informatics and relates to a method for constructing and analyzing a gene regulation network based on breast cancer. Background technique [0002] Genetic expression determines the phenotype and developmental state of cells and tissues. Common human diseases such as malignancies and neurodegenerative diseases can be traced to abnormal gene expression. Usually, genes are not expressed in isolation, and the expression of one gene can affect the expression of other genes, and is also affected by the expression of other genes. The interactions and interrelated regulatory relationships between genes form a gene regulatory network. Modeling and analysis of gene regulatory networks provides a genetic perspective for treatment and diagnosis of breast cancer disease. Therefore, constructing disease-related gene regulatory networks is of great significance for exploring human body mechanisms and disease treatment....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B5/00G16B25/00
Inventor 王之琼曲璐渲郭上慧霍岳阳高笑宇钱唯
Owner NORTHEASTERN UNIV LIAONING
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