Oral suspension for treating acute lymphoblastic leukemia and preparation method thereof
A technology of acute lymphocyte and oral suspension, which is applied in the directions of non-active ingredients medical preparations, liquid delivery, pharmaceutical formulations, etc., can solve the problems of poor thixotropy, difficult to dissipate bubbles, short validity period, etc., and achieves storage conditions. The effect of low requirements and low product impurity levels
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Embodiment 1
1000
[0063] The preparation process of the prescription:
[0064] ① Measure 90% of the total prescription amount of purified water, put it in the liquid mixing tank, and heat it to 50°C;
[0065] ②The speed of the blades of the liquid mixing tank is 50rpm, and the sweetener, bacteriostat, pH regulator, and suspending agent are dissolved in sequence;
[0066] ③Mix the mercaptopurine and poloxamer evenly in the form of dry powder, then add it to the solution under item ②, and stir until evenly dispersed;
[0067] ④ Adjust the pH to 4.5±0.1, add purified water to a sufficient amount;
[0068] ⑤Fill in soda-lime glass bottles, the volume of each bottle is 103mL.
Embodiment 2
1000
[0071] The preparation process of the prescription:
[0072] ① Measure 90% of the total prescription amount of purified water, put it in the liquid mixing tank, and heat it to 50°C;
[0073] ②The speed of the blades of the liquid mixing tank is 50rpm, and the sweetener, bacteriostat, pH regulator, and suspending agent are dissolved in sequence;
[0074] ③Mix the mercaptopurine and poloxamer evenly in the form of dry powder, then add it to the solution under item ②, and stir until evenly dispersed;
[0075] ④ Adjust the pH to 4.5±0.1, add purified water to a sufficient amount;
[0076] ⑤Fill in soda-lime glass bottles, the volume of each bottle is 103mL.
Embodiment 3
1000
[0079] The preparation process of the prescription:
[0080] ① Measure 90% of the total prescription amount of purified water, put it in the liquid mixing tank, and heat it to 50°C;
[0081] ②The speed of the blades of the liquid mixing tank is 50rpm, and the sweetener, bacteriostat, pH regulator, and suspending agent are dissolved in sequence;
[0082] ③Mix the mercaptopurine and poloxamer evenly in the form of dry powder, then add it to the solution under item ②, and stir until evenly dispersed;
[0083] ④ Adjust the pH to 4.5±0.1, add purified water to a sufficient amount;
[0084] ⑤Fill in soda-lime glass bottles, the volume of each bottle is 103mL.
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Abstract
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