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Pharmaceutical composition for treating constipation and application thereof

A technology for treating constipation and composition, applied in the field of medicine, can solve problems such as damage to defecation mechanism, unsatisfactory laxatives, adverse reactions, etc., reduce anal sphincter pressure, do not have compatibility problems, and are suitable for industrial production Effect

Inactive Publication Date: 2018-11-30
XIAN LIBANG PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although laxatives can relieve constipation symptoms in the short term, they cannot improve the long-term quality of life of patients, especially for chronic, habitual constipation, repeated lingering episodes of constipation, which seriously trouble patients, prone to anxiety and depression, and seriously affect quality of life. Psychologically, it produces obvious negative effects. At the same time, psychological disorders can affect the regulation of the brain-gut axis, further damage the defecation mechanism, make patients lack confidence and patience, and reduce treatment compliance
A 2014 web-based survey showed that 57% of patients were not completely satisfied with laxatives, 82% due to poor efficacy and 16% due to adverse effects
[0007] In view of the above studies, it can be seen that refractory constipation, chronic constipation, and habitual constipation in the elderly are relatively stubborn, and often a class of laxative drugs cannot achieve good therapeutic effects, and the treatment is difficult. Comprehensive treatment measures should be taken

Method used

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  • Pharmaceutical composition for treating constipation and application thereof
  • Pharmaceutical composition for treating constipation and application thereof
  • Pharmaceutical composition for treating constipation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] The preparation of embodiment 1 oral solution

[0069] prescription:

[0070]

[0071]

[0072] method:

[0073] Take 90ml of distilled water, add 0.01g of potassium sorbate, heat and stir to dissolve all, boil for 10 minutes, let cool to obtain solution ①; add 25.0g of sodium carboxymethyl starch raw material (degree of substitution 1) to solution ①, stir to make all Dissolve to obtain solution ②; add 10.0g of mannitol, 0.08g of citric acid, 0.02g of sodium citrate, 0.15g of aspartame and 0.1g of pineapple essence to the solution ②, stir well to dissolve completely, and obtain the solution③ ; Sodium hydroxide made (0.1mol / l) solution, slowly added to the solution ③, adjust the pH of the solution to 7 ~ 9, add distilled water to 100ml.

Embodiment 2

[0074] The preparation of embodiment 2 oral solution

[0075] prescription:

[0076]

[0077] method:

[0078] Raw materials pass through a 100-mesh sieve, auxiliary materials pass through a 80-mesh sieve, take 80ml of distilled water, add 0.01g of potassium sorbate, heat and stir to dissolve all, boil for 10 minutes, let cool, and obtain solution ①; add carboxymethyl starch sodium raw material to solution ① Drug (substitution degree 1) 20.0g, stir to make all dissolve, obtain solution ②; Add prucalopride 20.0mg to solution ②, stir to mix evenly, obtain solution ③; Add stevioside 0.1g and lemon Essence 0.01g, stir well to dissolve it completely to obtain solution ④; make a 1% (v / v) solution of hydrochloric acid, slowly add it to solution ④, adjust the pH of the solution to 7-9, add distilled water to 100ml .

Embodiment 3

[0079] The preparation of embodiment 3 oral solution

[0080] prescription:

[0081]

[0082] method:

[0083] Take 800ml of distilled water, add 0.1g of potassium sorbate, heat and stir to dissolve all, boil for 10 minutes, let cool, and obtain solution ①; add 100.0g of sodium carboxymethyl starch raw material (degree of substitution 1) to solution ①, stir to make all Dissolve to obtain solution ②; add 2.4 mg of lubiprostone to solution ②, stir to mix evenly, and obtain solution ③; add 1.0 g of stevioside and 0.1 g of lemon essence to solution ③, fully stir to make it dissolve completely, Obtain solution ④; make a 1% (v / v) solution of hydrochloric acid, slowly add it into solution ④, adjust the pH of the solution to 7-9, add distilled water to make it 1000ml.

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Abstract

The invention discloses the combined application of a pharmaceutical composition composed of water-soluble starch salt modified by carboxylic acid groups and gastrointestinal motility promoting drugsor secretion promoting drugs in the prevention and treatment of constipation, the pharmaceutical composition can be suitable for various functional constipation, especially has good curative effects on old age refractory constipation, chronic constipation, habitual constipation, drug-induced constipation and the like, has slight adverse reactions, and can be suitable for various crowds. The representative drug of the water-soluble starch salt modified by the carboxylic acid groups is sodium carboxymethyl starch, and the gastrointestinal motility promoting drugs or secretion promoting drugs areselected from dopamine receptor antagonist, 5-HT4 receptor agonist, motilin receptor agonist, chloridion channel activator, guanylate cyclase agonist. The two components are combined according to a suitable weight ratio and can be prepared into any oral pharmaceutical dosage form including oral solution, oral suspension, granule, powder, tablet, capsule and the like.

Description

technical field [0001] The present invention relates to a pharmaceutical composition and its pharmaceutical use, in particular to a pharmaceutical composition in which a carboxylic acid group-modified water-soluble starch salt and a gastrointestinal motility agent or a secretory agent are the active ingredients of the medicine and its use for constipation The medical use of treatment, the invention belongs to the field of medicine. Background technique [0002] Constipation refers to changes in normal defecation patterns, decreased stool frequency, and difficulty in defecation. Constipation is a common clinical complex symptom. It is reported that the prevalence of constipation in the population is as high as 27%. Chronic constipation has been underestimated by people for quite a long time in the past. In recent years, it may be due to people's unreasonable diet structure, sedentary, reduced physical labor and other reasons. The prevalence of constipation has increased year ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/4525A61K31/454A61K31/558A61K31/7048A61K31/7052A61K31/718A61K38/10A61P1/10
CPCA61K31/4525A61K31/454A61K31/558A61K31/7048A61K31/7052A61K31/718A61K38/10A61K45/06A61P1/10A61K2300/00
Inventor 陈涛卫东卢伍党
Owner XIAN LIBANG PHARMA TECH
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