Traditional Chinese medicine composition for treating vomit and application thereof

The technology of a composition and a traditional Chinese medicine is applied in the field of traditional Chinese medicine compositions for treating vomiting, can solve problems such as few external dosage forms, and achieve the effects of simple preparation, remarkable curative effect and simple preparation process

Inactive Publication Date: 2019-02-05
SECOND AFFILIATED HOSPITAL SECOND MILITARY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drugs commonly used to treat vomiting are mainly intravenous drugs, followed by oral administration, and there are fewer external dosage forms

Method used

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  • Traditional Chinese medicine composition for treating vomit and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A preparation method of a traditional Chinese medicine composition for treating vomiting includes the following steps:

[0044] Clove 3g, persimmon stem 6g, ginger 6g, cassia twig 9g, magnolia root 10g, ginger pinellia 15g, and Huoxiang 6g.

[0045] Wash the above Chinese medicine, remove impurities, put it in a container and add water to submerge the medicinal materials. After 30 minutes, boil on high fire until boiling, then simmer for 1 hour, filter out the medicinal juice, pack it in bags, 200mL each, morning and evening Take a bag.

Embodiment 2

[0047] A transdermal absorption patch of traditional Chinese medicine for the treatment of vomiting for external use is composed of the following seven layers: The first layer, the backing layer 11, is a non-woven fabric (PMC135040, Aoteron Non-woven Cloth Co., Ltd.); the second layer, the heating layer 12, the raw material is a polymer film (HX type, Zhushi Pharmaceutical Group) synthesized from iron, activated carbon, etc., which can react with oxygen to release heat; the third layer, That is, the isolation layer 13 is made of polymer isolation membrane (PE type, Shanghai Dianfan Medical Technology Co., Ltd.); the fourth layer, the Chinese medicine controlled release layer 14, is made of polymer microporous framework membrane material, which exerts a lasting curative effect ; The fifth layer, the quick-acting layer 15 of traditional Chinese medicine, is made of medical microporous film; the sixth layer, the viscose layer 16, is made of gelatin; the seventh layer, the protectiv...

Embodiment 3

[0058] Example 3: Clinical observation of the present invention

[0059] Source of cases:

[0060] The cases were derived from chemotherapy and vomiting patients in the Department of Traditional Chinese Medicine of Shanghai Changzheng Hospital from June 2016 to June 2017.

[0061] Inclusion criteria:

[0062] Malignant tumor patients receiving cisplatin or cisplatin-based combination chemotherapy or malignant tumor patients receiving doxorubicin or doxorubicin-based combination chemotherapy; age ≥18 years old, gender is not limited, KPS ≥60 points, Expected to survive for more than 3 months; blood, liver, and kidney functions are normal, and there are indications for chemotherapy; newly treated patients or more than 4 weeks after the last chemotherapy; patients have good compliance and informed consent.

[0063] Efficacy evaluation

[0064] 1. Nausea scale: no nausea (-); slight nausea, does not affect eating (+); obvious nausea, affects eating (++); severe nausea, can not eat and stay ...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating vomit. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 1 to 9parts of flos caryophylli, 1 to 9 parts of calyx kaki, 1 to 9 parts of rhizoma zingiberis recens, 1 to 9 parts of cassia twig, 1 to 15 parts of cortex magnoliae officinalis, 1 to 15 parts of rhizomapinelliae preparata, and 1 to 10 parts of herba pogostemonis. The invention further discloses an externally-used traditional Chinese medicine transdermal absorption patch for treating vomit, and the traditional Chinese medicine transdermal absorption patch adopts the traditional Chinese medicine composition for treating the vomit as an active ingredient. The traditional Chinese medicine composition for treating the vomit is wide in raw material source, simple in preparation, convenient in use, and through clinical and pharmacological research, the traditional Chinese medicine composition has good curative effect on the vomit caused by chemotherapy, carsickness, ship sickness and the like; and the existing vomit prevention drug is generally in a syringe form and is inconvenient to use, andthe traditional Chinese medicine compound formula for external use has good application prospect.

Description

Technical field [0001] The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for treating vomiting and its application. Background technique [0002] Nausea and vomiting are common side effects during chemotherapy. Most chemotherapy drugs have different degrees of gastrointestinal reactions. However, the gastrointestinal reactions caused by cisplatin and adriamycin are more serious, and sometimes they have become factors that limit the increase in chemotherapy doses. , And affect the completion of the chemotherapy plan. [0003] The mechanism of vomiting: the mechanism of nausea and vomiting caused by chemotherapy is mainly related to the vomiting center and central chemoreceptors. The vomiting center is located in the reticular structure on the side of the oblongata, and receives incoming signals from the vestibule of the cerebellum, the visceral branch of the vagus nerve, the viscera...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/70A61P1/08
CPCA61K9/0004A61K9/7053A61K36/44A61K36/532A61K36/54A61K36/575A61K36/61A61K36/8888A61K36/9068A61K2236/331A61K2236/39A61K2236/53A61P1/08A61K2300/00
Inventor 修丽娟岳小强庞涛张映城刘煊矫健鹏孙昱玮
Owner SECOND AFFILIATED HOSPITAL SECOND MILITARY MEDICAL UNIV
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