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Device for preparing dissolution media

A dissolution medium and main control device technology, applied in the general layout of liquid degassing, chemical instruments and methods, liquid degassing, etc., can solve the problems of limiting drug dissolution, affecting drug credibility, and deviation of experimental results, etc., to achieve High degree of automation and preparation efficiency, avoid medium concentration loss, ideal degassing effect

Pending Publication Date: 2019-02-15
深圳市华溶分析仪器有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Degassing treatment can discharge the gas dissolved in the dissolution medium, so as to avoid these gases forming tiny bubbles on the surface and inside of the drug. These bubbles will isolate the drug from the solvent, limit the dissolution of the drug, and lead to deviations in experimental results, which in turn will affect the drug in vivo. Confidence in Dissolution Predictions
[0005] The traditional way of degassing the dissolution medium is to use a vacuum pump to degas the negative pressure. First, put a large amount of purified water into a large airtight container for heating. Part of the volatilization into gas, and then vacuuming will cause the concentration of the dissolution medium to change, so the traditional degassing method can only be degassed first, and then the dissolution medium is prepared. The disadvantages of this method include the following two points: 1) After taking out the degassed 2) In order to improve the efficiency, the volume of the sealed container can only be increased to heat and degas a large amount of purified water at one time, which will cause the entire system to be bulky and the vacuum pump to run noisy Large, slow heating time-consuming, low efficiency, and need to manually distribute the volume later, low degree of automation, inconvenient to use

Method used

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  • Device for preparing dissolution media
  • Device for preparing dissolution media
  • Device for preparing dissolution media

Examples

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Embodiment Construction

[0021] The present invention is further described below in conjunction with specific embodiment:

[0022] As an example, this embodiment is used to prepare a device for dissolution medium, such as Figures 1 to 4 As shown, it includes a main control device and a frame 1, and the frame 1 is provided with an input pipeline, an output pipeline, a vacuum mechanism, a heating water tank 13 and a heating rod.

[0023] Specifically, the frame 1 includes a top plate, a vertical plate and a bottom plate, the three are arranged in an I-shape, and are reinforced by setting columns at the four corners.

[0024] Input pipeline comprises input pipeline 11, and output pipeline comprises output pipeline 14, and input pipeline 11 is provided with electromagnetic valve 15, heating water tank 13, and output pipeline 14 is provided with electromagnetic valve 12, and input pipeline 11, output pipeline 14 and common pipeline 17 are connected by a tee, and the public pipeline 17 is connected with t...

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Abstract

The invention discloses a device for preparing dissolution media. The device comprises a master control device and a rack, wherein an input pipeline, an output pipeline, a vacuumizing mechanism as well as a container and a device which are used for heating are arranged on the rack; electromagnetic valves are arranged on both the input pipeline and the output pipeline; the output end of the input pipeline and the input end of the output pipeline are connected with the vacuumizing mechanism; the container and the device which are used for heating cooperate with each other, the container is arranged on the input pipeline and sealed with the outside; the master control device is connected with the vacuumizing mechanism, the electromagnetic valves and the device used for heating. The device canbe used for directly heating and degassing the prepared dissolution media, the heating and degassing processes are isolated from the outside, secondary preparation is not needed after degassing, thedegassing effect is quite ideal, medium concentration loss and secondary gas dissolving are avoided, and the device is concise in structure and high in automation degree and preparation efficiency andhas effects of small size and low noise.

Description

technical field [0001] The invention relates to the field of preparation of a drug dissolution medium, in particular to a device for preparing a dissolution medium. Background technique [0002] The efficacy and safety of drugs are closely related to their bioavailability. After oral administration of solid preparations, the absorption of the drug mainly depends on its dissolution rate under physiological conditions, and the dissolution test of the drug in vitro is conducive to the prediction of its in vivo conditions. [0003] The dissolution medium is mainly used to simulate the dissolution of the drug by the human body in vitro, and provide a reference for the prediction of the dissolution rate of the drug in vivo. At present, the commonly used dissolution medium is water, followed by an acid solution prepared by using water as a solvent and hydrochloric acid, acetic acid, phosphoric acid, etc. When the dissolution medium is an acid solution, it is often used to simulat...

Claims

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Application Information

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IPC IPC(8): B01D19/00
CPCB01D19/00B01D19/0068
Inventor 祝锦敏
Owner 深圳市华溶分析仪器有限公司
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