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A kind of modified clay and its preparation method and application

A clay and modification technology, applied in the field of modified clay and its preparation, can solve the problems of lack of broad-spectrum bactericidal properties, secondary damage to human skin, long time required for sterilization, etc. Low requirements and high sterilization efficiency

Active Publication Date: 2021-01-05
CHINA UNIV OF GEOSCIENCES (BEIJING)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] (1) The bactericidal effect is poor, and the dosage is large, and the application amount must be greater than 90g / L to exert the bactericidal effect;
[0006] (2) The time required for sterilization is long and the efficiency is low. Generally, it takes about 2 months to cure the affected area;
[0008] (4) Sterilization pH9, easy to cause secondary damage to human skin;
[0009] (5) It does not have broad-spectrum bactericidal performance, and the bactericidal effect on some strains (such as Staphylococcus aureus S.aureus) is extremely limited

Method used

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  • A kind of modified clay and its preparation method and application
  • A kind of modified clay and its preparation method and application
  • A kind of modified clay and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0055] According to a preferred embodiment of the present invention, the reducing agent is a chemical reducing agent and / or a biological reducing agent, preferably a chemical reducing agent.

[0056] The inventors have found through research that when the structural ferrous iron is oxidized under the mild regulation of the near-neutral skin, a large amount of active oxygen species (ROS) can be released, especially hydroxyl radicals (OH). The active oxygen species attack cells, Oxidize the lipid molecules on the surface of the cell membrane, expand the permeability of the cell membrane, and then allow the metal ions (Fe) in the clay to enter the cell, catalyzing the intracellular O 2 and H produced by cellular respiration 2 o 2 etc., continue to generate reactive oxygen species, and further attack intracellular components and structures, thereby killing bacteria.

[0057] However, iron oxides and iron-containing clay minerals widely distributed in natural depositional environ...

Embodiment 1

[0145] (1) Prepare iron-rich nontronite (NAu-2) with a particle size <2 μm according to the following steps:

[0146] (1.1) Use an agate mortar to grind the nontronite to particles with a particle size of 200 mesh (<74 μm);

[0147] (1.2) Soak 30g of nontronite in 600ml of NaCl (concentration: 500mM; 29.22g / L) solution for 24h (make sure the clay concentration is 50g / L);

[0148] (1.3) Add the rotor into the Erlenmeyer flask containing clay and NaCl liquid, and rotate and stir in a magnetic stirrer for 24 hours; for uniform mixing, ultrasonic and stirring methods can be used simultaneously (every ultrasonic 2h, stirring 1h), until the clay is mixed with Mix the NaCl solution evenly;

[0149] (1.4) Divide the evenly mixed clay solution into 50ml centrifuge tubes, centrifuge at 4000G for 5min, and pour off the supernatant; Clear clay particles < 2μm;

[0150] (1.5) Divide the centrifuged supernatant into dialysis bags, seal and place them, fill a large beaker with a certain a...

Embodiment 2～3

[0166] The method used in Examples 2-3 is similar to that of Example 1, the difference is that the buffer solution in (4) is PIPES and HEPES respectively, and the adjusted pH of the solution is 7 and 8 respectively.

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Abstract

The invention discloses modified clay, a preparation method and the application thereof. The modified clay is obtained by sequentially mixing iron-containing natural clay with an intercalating agent and a reducing agent. The invention also discloses a bactericidal composition and a preparation method thereof. The bactericidal composition comprises the modified clay as a main component, and also comprises a buffer for maintaining the pH of the composition. The modified clay has a broad-spectrum antibacterial property, is mild to the skin, and has a good bactericidal effect and high efficiency;and the preparation method of the modified clay is easy to operate, controllable in condition, and low in requirements for equipment.

Description

technical field [0001] The invention belongs to the field of preparation of wound sterilization materials, and in particular relates to a modified clay and its preparation method and application. Background technique [0002] At present, the main way to treat skin infections is external application or oral administration of various antibiotics, such as ticarcillin-clavulanic acid, ceftazidime, minocycline, levofloxacin oxacin), chloramphenicol β-lactams (β-lactams), quinolones (quinolones), aminoglycosides (aminoglycosides), tetracyclines (tetracycline), etc. (Fan Jing, Xu Jinhua. Quinolones antibiotics in Progress in the treatment of skin infectious diseases [J]. World Clinical Medicine, 2007 (9): 543-545; Zhang Sijia, Li Ping, Wang Nie. Research on external application of traditional Chinese medicine in the treatment of skin and soft tissue infections [J]. Liaoning University of Traditional Chinese Medicine Journal, 2011(4):69-72.). Antibiotic bactericidal materials main...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B33/40A61K33/26A61K47/36A61P31/04
CPCA61K33/26A61K47/36A61P31/04C01B33/40C01P2002/72
Inventor 夏庆银董海良王曦
Owner CHINA UNIV OF GEOSCIENCES (BEIJING)
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