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A method for studying oral release of flavoring substances from oral smokeless tobacco products

A technology of smokeless tobacco and aroma substances, applied in the direction of instruments, measuring devices, scientific instruments, etc., can solve the problems of not truly and effectively simulating the state of the human oral cavity, and not exploring the influence of aroma substances release, etc., to achieve strong controllability , Avoid ethical and moral restrictions, and the effect of simple operation

Active Publication Date: 2022-02-01
CHINA TOBACCO YUNNAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, they all use a fixed saliva flow rate to explore the influence of different influencing factors, but do not explore the pressure factors (the use of pouched snus is generally placed between the gums and lips) and the saliva flow rate (saliva flow rate at different times when the mouth is stimulated) different release rates) on the release of aroma substances
Does not truly and effectively simulate the state of the human body when smoking smokeless tobacco products in the oral cavity

Method used

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  • A method for studying oral release of flavoring substances from oral smokeless tobacco products
  • A method for studying oral release of flavoring substances from oral smokeless tobacco products
  • A method for studying oral release of flavoring substances from oral smokeless tobacco products

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Experimental program
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Effect test

Embodiment 1

[0052] A method for studying oral cavity release of flavoring substances in oral smokeless tobacco products, comprising the steps of:

[0053] Step (1), screening of oral smokeless tobacco products: select a plurality of oral smokeless tobacco products to be studied for weight detection, and calculate the average value and variance of the single weight of the product; after that, select Products whose weight range is within the range of the average value ± 2 times the variance are used as samples for subsequent determination;

[0054] The type of oral smokeless tobacco products is snus;

[0055] Step (2), determination of simulated dissolution parameters: select a number of healthy volunteers to suck the samples screened in step (1) in a natural state, and collect residual samples and saliva of each volunteer at a predetermined time point, Use one sample per time point;

[0056] Step (3), determination of oral release of flavor substances in vivo experiments: use gas chromat...

Embodiment 2

[0061] A method for studying oral cavity release of flavoring substances in oral smokeless tobacco products, comprising the steps of:

[0062] Step (1), screening of oral smokeless tobacco products: select 50 pieces of a certain oral smokeless tobacco product to be studied for weight detection, and calculate the average value and variance of the single weight of the product; after that, select Products whose weight range is within the range of the average value ± 1 times the variance shall be used as samples for subsequent determination;

[0063] The types of oral smokeless tobacco products include tobacco smoke;

[0064] Step (2), determination of simulated dissolution parameters: select a number of healthy volunteers aged 18-55 to smoke the samples screened in step (1) in a natural state, and collect residual samples at a predetermined time point and the saliva of each volunteer, using one sample at each time point;

[0065] The collection time point of the residual sample...

Embodiment 3

[0074] A method for studying oral cavity release of flavoring substances in oral smokeless tobacco products, comprising the steps of:

[0075] Step (1), screening of oral smokeless tobacco products: select 100 pieces of a certain oral smokeless tobacco product to be studied for weight detection, and calculate the average value and variance of the single weight of the product; after that, select Products whose weight range is within the range of the average value ± 3 times the variance are used as samples for subsequent determination;

[0076] The type of the oral smokeless tobacco product is paste-like smoke.

[0077] Step (2), determination of simulated dissolution parameters: select a number of healthy volunteers aged 18-55 to smoke the samples screened in step (1) in a natural state, and collect residual samples at a predetermined time point and the saliva of each volunteer, using one sample at each time point;

[0078] The collection time point of the residual sample and...

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Abstract

The invention relates to a method for studying the oral cavity release of flavor substances of oral smokeless tobacco products, and belongs to the technical field of analysis of oral smokeless tobacco products. The method comprises the steps of screening oral smokeless tobacco products, determining simulated dissolution parameters, measuring oral cavity release of flavoring substances in vivo experiments, and simulating in vitro experiments. The present invention uses in vivo experiments to determine in vitro research parameters, and uses a fully simulated chewing machine to test samples in vitro. The device used can completely simulate the state of human mouth smoking smokeless tobacco products. The flow rate and oral temperature can be adjusted, and the controllability is strong, the stability is high, and the operation is simple. The research method of the present invention can well avoid the influence of subjective and objective factors brought about by traditional artificial tasting, avoid the ethical and moral constraints of a large number of people's experiments, save experiment costs and reduce the health hazards caused by human experiments , suitable for batch studies of samples.

Description

technical field [0001] The invention belongs to the technical field of analyzing smokeless tobacco products for oral use, and in particular relates to a method for studying the release of aroma substances in the oral cavity of smokeless tobacco products for oral use, by which the oral smokeless tobacco products for oral use can be studied and analyzed Dissolution of aroma substances. Background technique [0002] Smokeless Tobacco products (STPs for short) refer to tobacco products that are smoked directly through the mouth or nose without burning. Compared with traditional cigarettes, they have fewer harmful components and are less harmful; at the same time, they do not produce second-hand smoke. To a certain extent, it can alleviate the contradiction between smoking ban and smoking in public places, and satisfy the physiological needs of smokers to a certain extent. Smokeless tobacco products come in various forms such as snus in pouches, snus and chewing tobacco, among w...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 杨继赵杨赵辉段沅杏刘春波申钦鹏杨柳陈永宽刘志华缪明明
Owner CHINA TOBACCO YUNNAN IND
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